| Identification | More | [Name]
Thioflavine T | [CAS]
2390-54-7 | [Synonyms]
BASIC YELLOW 1
CI 49005
CI NO 49005
LABOTEST-BB LT00451909
SETOFLAVINE T
THIOFLAVINE T
THIOFLAVINE TG
THIOFLAVINE T, TCN, TG
THIOFLAVIN T
THT
2-[4-(dimethylamino)phenyl]-3,6-dimethyl-benzothiazoliuchloride
Benzothiazolium,2-[4-(dimethylamino)phenyl]-3,6-dimethyl-,chloride
2-[4-(dimethylamino)phenyl]-3,6-dimethylbenzothiazolium chloride
THIOFLAVINE T, FOR MICROSCOPY
ThioflavineTC.I.49005
THIOFLAVINET,TG
Basic yellow 1 (C.I. 49005)
C.I. Basic Yellow 1
Basic Yellow1, Thioflavine T
4-(3,6-Dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethylaniline chloride | [EINECS(EC#)]
219-228-9 | [Molecular Formula]
C17H19ClN2S | [MDL Number]
MFCD00011944 | [Molecular Weight]
318.86 | [MOL File]
2390-54-7.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow to ochre-yellow powder | [Melting point ]
211-212 °C (decomp) | [density ]
1.301g/cm3 at 20℃ | [vapor pressure ]
0Pa at 25℃ | [storage temp. ]
Store below +30°C. | [solubility ]
methanol: soluble1mg/mL | [Colour Index ]
49005 | [form ]
Powder | [color ]
Yellow to ochre-yellow | [Water Solubility ]
water: 5mg/mL | [BRN ]
3922452 | [InChI]
InChI=1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1 | [InChIKey]
JADVWWSKYZXRGX-UHFFFAOYSA-M | [SMILES]
C1(=[N+](C)C2C=CC(C)=CC=2S1)C1C=CC(N(C)C)=CC=1.[Cl-] | [LogP]
3.02 at 25℃ and pH7.98 | [Uses]
Textile dyeing, fluorescent sign paints, in combination
with green or blue pigments to produce
brilliant greens, phosphotungstic pigments. | [CAS DataBase Reference]
2390-54-7(CAS DataBase Reference) | [EPA Substance Registry System]
2390-54-7(EPA Substance) |
| Safety Data | Back Directory | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [RIDADR ]
2811 | [WGK Germany ]
3
| [TSCA ]
Yes | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
32041300 |
| Hazard Information | Back Directory | [Chemical Properties]
yellow to ochre-yellow powder | [Definition]
ChEBI: Thioflavine T is an organic chloride salt having 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium as the counterion. It is widely used to visualise and quantify the presence of amyloids, both in vitro and in vivo. It has a role as a fluorochrome, a histological dye and a geroprotector. It contains a thioflavin T cation. | [Preparation]
4-(6-Methyl-2,3-dihydrobenzo[d]thiazol-2-yl)benzenamine?with methanol and hydrochloric acid or sulfuric acid, at 160 ~ 170 ℃ methylation under pressure. | [General Description]
Thioflavin T is a benzothiazole dye that increases in fluorescence upon binding to amyloid. Thioflavin T has been used in histology and for protein characterization. | [Biochem/physiol Actions]
Cell permeable: yes | [storage]
Store at -20°C | [Properties and Applications]
colourful green light yellow. Soluble in cold water, soluble in hot water for yellow, easily soluble in ethanol and yellow, with green fluorescent. The strong sulfuric acid to colorless, a green fluorescent, diluted into light yellow.
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Standard( Silk )
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Light Fastness
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Persperation Fastness
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Ironing Fastness
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Soaping
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Fading
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Stain
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Fading
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Stain
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Fading
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Stain
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C
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3
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2-3
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4
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1
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| [Purification Methods]
Crystallise the chloride from *benzene/EtOH (1:1). [Beilstein 27 III/IV 5052.] |
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