| Identification | More | [Name]
TRIMETHYLSILYL ISOTHIOCYANATE | [CAS]
2290-65-5 | [Synonyms]
ISOTHIOCYANATOTRIMETHYLSILANE
TRIMETHYLSILYL ISOTHIOCYANATE
isothiocyanatotrimethyl-silan
Silane, isothiocyanatotrimethyl-
Trimethylsilylisothiocyanate,94% | [EINECS(EC#)]
218-929-7 | [Molecular Formula]
C4H9NSSi | [MDL Number]
MFCD00004797 | [Molecular Weight]
131.27 | [MOL File]
2290-65-5.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colorless to light yellow liquid | [Melting point ]
−32.8 °C(lit.) | [Boiling point ]
143 °C(lit.) | [density ]
0.931 g/mL at 25 °C(lit.)
| [vapor density ]
>1 (vs air)
| [refractive index ]
n20/D 1.482(lit.)
| [Fp ]
95 °F
| [storage temp. ]
2-8°C
| [form ]
liquid | [Specific Gravity]
0.931 | [Water Solubility ]
Reacts with water. | [Hydrolytic Sensitivity]
8: reacts rapidly with moisture, water, protic solvents | [Sensitive ]
Moisture Sensitive | [BRN ]
1745262 | [InChIKey]
XLTUPERVRFLGLJ-UHFFFAOYSA-N | [CAS DataBase Reference]
2290-65-5(CAS DataBase Reference) | [EPA Substance Registry System]
Isothiocyanatotrimethylsilane (2290-65-5) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R10:Flammable.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin .
R42:May cause sensitization by inhalation. | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 1992 3/PG 3
| [WGK Germany ]
3
| [F ]
10-19-21 | [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
II | [HS Code ]
29319090 |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless to light yellow liquid | [Uses]
Trimethylsilyl isothiocyanate was used as derivatizing reagent during the synthesis of amino acid thiohydantoins. | [Uses]
Trimethylsilyl isothiocyanate is used as derivatizing reagent during the synthesis of amino acid thiohydantoins. It participates in ring opening reaction of N-substituted aziridines and cyclohexene oxide. | [General Description]
Trimethylsilyl isothiocyanate (TMS-ITC) reacts with fullerene-mixed peroxide C60(O)(OOtBu)4 to yield isothiocyanate derivative C60(NCS)(OH)(OOtBu)4. TMS-ITC undergoes condensation with ethyl 2-benzylamino-5-methyl-3-phenylcyclopent-1-enecarboxylate to yield 1-benzyl-5-methyl-7-phenyl-2-thioxo-1,2,3,5,6,7-hexahydrocyclopentapyrimidin-4-one. It participates in ring opening reaction of N-substituted aziridines and cyclohexene oxide. | [Purification Methods]
The 1H NMR spectrum should have only one peak; if not purify it by repeated fractionation in an all-glass system using a 50cm (4mm internal diameter) column without packing. [Anderson J Am Chem Soc 69 3049 1947, Fehér & Blümcke Chem Ber 90 1934 1957, Neidleim & Hege Synthesis 51 1975, Beilstein 4 III 1861, 4 IV 4011.] |
|
| Company Name: |
Alfa Aesar
|
| Tel: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|