| Identification | Back Directory | [Name]
WAY-151932 | [CAS]
220460-92-4 | [Synonyms]
VNA-932
WAY-151932
Methanone, [2-chloro-4-(3-methyl-1H-pyrazol-1-yl)phenyl]-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-yl- | [Molecular Formula]
C23H19ClN4O | [MDL Number]
MFCD05662330 | [MOL File]
220460-92-4.mol | [Molecular Weight]
402.88 |
| Chemical Properties | Back Directory | [Boiling point ]
630.6±55.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
0.04±0.12(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
WAY-151932 is a vasopressin V2-receptor agonist with IC50 of 80.3 nM and 778 nM in human-V2 binding and V1a binding assay. | [Biological Activity]
WAY-151932 is an antidiuretic hormone V2 receptor agonist with IC50 of 80.3 and 778 nM in human V2 and V1a binding assays, respectively. | [in vitro]
WAY-151932 (VNA-932) stimulates cAMP formation in LV2 cells expressing the hV 2 receptors in a dose-dependent manner with an EC 50 of 0.74±0.07 nM. | [in vivo]
Oral administration of WAY-151932 (VNA-932) to water-loaded conscious rats produces a dose-dependent decrease in urine volume (ED 50 =0.14 mg/kg, 2.5% starch in water vehicle) and a corresponding increase in osmolality without altering the urine electrolyte excretion profile. | [target]
IC50: 80.3 nM (human-V2 binding), 778 nM (human-V1a binding) | [storage]
Store at -20°C | [References]
[1] Molinari AJ, et al. Identification and synthesis of major metabolites of Vasopressin V2-receptor agonist WAY-151932, and antagonist, Lixivaptan. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5796-800. DOI:10.1016/j.bmcl.2007.08.053
[2] Failli AA, et al. Pyridobenzodiazepines: a novel class of orally active, vasopressin V2 receptor selective agonists. Bioorg Med Chem Lett. 2006 Feb 15;16(4):954-9. DOI:10.1016/j.bmcl.2005.10.107 |
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