| Identification | More | [Name]
ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER | [CAS]
21085-72-3 | [Synonyms]
EOS-61715
Acetobromo-aL
Einecs 244-203-4
ucuronicacidmethyL
Methyl α-Acetobromoglucuronate
Methyl a-Acetobromoglucuronate
BROMOMETHYLTRIACETYL GLUCURONATE
Methyl acetobromo-α-D-glucuronate
METHYL ACETOBROMO-ALPHA-D-GLUCURONATE
acetobromo-α-d-glucuronic acid methyl ester
ACETOBROMO-A-D-GLUCURONIC ACID, METHYL ESTER
Acetobromo- α-D-glucuronic acid methyl ester
Acetobromo-α-D-glucuronic Acid Methyl Ester Α-D
ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER
Acetobromo-α-D-glucuronic acid methyl ester ,98%
1-BROMO-1-DEOXY-2,3,4-TRI-0-ACETYL-Α-D-GLUCURONICACID
1-Bromo-2,3,4-tri-O-acetyl-a-D-glucuronidemethylester
Acetobromo-alpha-D-glucuronic acid, methyl ester 95+%
Methyl(tri-O-acetyl-α-D-glucopyranosyl bromide)uronate
1-Bromo-2,3,4-tri-O-acetyl-α-D- glucuronide methyl ester
Methyl tri-O-acetyl-1-broMo-1-deoxy-α-D-glucopyranuronate
methyl tri-O-acetyl-1-bromo-1-deoxy-α-D-glucopyranuronate
ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER USP/EP/BP
1-Bromo-2,3,4-tri-O-acetyl-α-D-glucuronic Acid Methyl Ester
1-Bromo-2,3,4-tri-O-acetyl-α-D-glucuronic Acid Methyl Ester
methyl tri-O-acetyl-1-bromo-1-deoxy-alpha-D-glucopyranuronate
1-BROMO-2,3,4-TRI-O-ACETYL-ALPHA-D-GLUCURONIC ACID METHYL ESTER
METHYL 2,3,4-TRI-O-ACETYL-1-BROMO-1-DEOXY-A-D-GLUCOPYRANURONATE
Bromo-2,3,4-tri-O-acetyl-a-d-glucopyranuronic Acid Methyl Ester
Acetobromo-α-D-glucuronic Acid Methyl Ester (contains 2% CaCO3)
Bromo-2,3,4-tri-O-acetyl-α-d-glucopyranuronic Acid Methyl Ester
Methyl 2,3,4-Tri-O-acetyl-alpha-D-glucopyranosyluronate Bromide
6-O-Methyl-2-O,3-O,4-O-triacetyl-α-D-glucopyranuronosyl bromide
2-O,3-O,4-O-Triacetyl-6-O-methyl-6-oxo-α-D-glucopyranosyl bromide
1-Bromo-2,3,4-tri-O-acetyl-a-D-glucuronide methyl ester - 1% CaCO3
1-Bromo-1-deoxy-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester
BROMO-2,3,4-TRI-O-ACETYL-ALPHA-D-GLUCOPYRANURONIC ACID METHYL ESTER
Methyl 1-bromo-1-deoxy-2,3,4-tri-O-acetyl-alpha-D-glucopyranuronate
1-Bromo-1-deoxy-2,3,4-tri-O-acetyl-ALPHA-D-glucuronide methyl ester
1-Bromo-1-deoxy-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester
alpha-d-glucopyranuronicacid,1-bromo-1-deoxy-,methylester,triacetate
Methyl 2,3,4-tri-O-acetyl-1-bromo-1-deoxy-alpha-D-glucopyranosyluronate
(2,3,4-tri-o-acetyl-α-d-glucopyranosyl bromide)uronic acid methyl ester
METHYL (2S,3S,4S,5R,6R)-3,4,5-TRIS(ACETYLOXY)-6-BROMOOXANE-2-CARBOXYLATE
2,3,4-Tri-O-acetyl-1-bromo-1-deoxy-α-D-glucopyranuronic acid methyl ester
2,3,4-Tri-O-acetyl-1-bromo-1-deoxy-α-D-glucopyranuronic acid methyl ester
2-O,3-O,4-O-Triacetyl-6-O-methyl-6-C-oxo-1-bromo-1-deoxy-α-D-glucopyranose
(2,3,4-TRI-O-ACETYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE)URONIC ACID METHYL ESTER
α-D-Glucopyranuronic acid, 1-bromo-1-deoxy-, methyl ester, 2,3,4-triacetate
1-Bromo-1-deoxy-2-O,3-O,4-O-triacetyl-α-D-glucopyranuronic acid methyl ester
2-O,3-O,4-O-Triacetyl-1-bromo-1-deoxy-α-D-glucopyranuronic acid methyl ester
Methyl (3S,4R,6R)-3,4,5-tris(acetoxy)-6-bromotetrahydro-2H-pyran-2-carboxylate
2,3,4-TRI-O-ACETYL-1-BROMO-1-DEOXY-ALPHA-DGLUCOPYRANOSIDURONIC ACID METHYL ESTER
(2R,3R,5S)-2-bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
(2S,3S,4S,5R,6R)-methyl 3,4,5-triacetoxy-6-bromo-tetrahydro-2H-pyran-2-carboxylate
(2R,3R,4S,5S,6S)-2-BroMo-6-(Methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
2,3,4-Trideoxy-2,3,4-triacetoxy-1-bromo-1-deoxy-α-D-glucopyranuronic acid methyl ester
Methyl acetobromo-α-D-glucuronate, Bromo-2,3,4-tri-O-acetyl-α-D-glucopyranuronic acid methyl ester, (2,3,4-Tri-O-acetyl-α-D-glucopyranosyl bromide)uronic acid methyl ester | [EINECS(EC#)]
244-203-4 | [Molecular Formula]
C13H17BrO9 | [MDL Number]
MFCD00061613 | [Molecular Weight]
397.17 | [MOL File]
21085-72-3.mol |
| Chemical Properties | Back Directory | [Appearance]
White Crystalline Solid | [Melting point ]
80-110 °C(lit.)
| [Boiling point ]
388.6±42.0 °C(Predicted) | [density ]
1.52 | [storage temp. ]
−20°C
| [solubility ]
Acetonitrile (Slightly), Chloroform (Slightly, Heated, Sonicated), Dichlorometha | [form ]
Crystalline Powder or Solid | [color ]
White to gray | [optical activity]
[α]/D 188 to 198 °, c =1% (w/v) in ethyl acetate | [Usage]
Antitumor agent | [BRN ]
96281 | [Stability:]
Moisture and Temperature Sensitive | [InChIKey]
BCDVKFMSIQGEHB-CIQUZCHMSA-N | [CAS DataBase Reference]
21085-72-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36/37/38 | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [F ]
3-8-10-21 | [Hazard Note ]
Irritant/Store Cold under-20oC | [HS Code ]
29189900 |
| Questions And Answer | Back Directory | [Uses]
Acetobromo-α-D-glucuronic acid methyl ester is used for the synthesis of HMR1098-S-glucuronide methyl ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.
Acetobromo-α-D-glucuronic acid methyl ester is used for the synthesis of water-soluble glucuronide derivatives of Camptothecin, which is used for cancer prodrug monotherapy and antibody-directed enzyme prodrug therapy (ADEPT).
Acetobromo-α-D-glucuronic acid methyl ester is used for the synthesis of glucuronide prodrug compounds of Janus kinase (JAK) inhibitor tofacitinib, which could be cleaved by β-glucuronidase enzymes such as those produced by the microbiome in the gastrointestinal tract, thereby increasing levels of tofacitinib at the site of gastrointestinal inflammation and limiting the systemic exposure of tofacitinib when treating localized inflammatory diseases.
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