| Identification | Back Directory | [Name]
8-METHYLTHIOGUANOSINE | [CAS]
2104-66-7 | [Synonyms]
8-METHYLTHIOGUANOSINE
Guanosine, 8-(methylthio)- | [Molecular Formula]
C11H15N5O5S | [MDL Number]
MFCD01318034 | [MOL File]
2104-66-7.mol | [Molecular Weight]
329.33 |
| Hazard Information | Back Directory | [Uses]
8-(Methylthio)guanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1]. | [References]
[1] Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51. DOI:10.1073/pnas.0631696100 |
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