| Identification | More | [Name]
2-Amino-6-chloropurine-9-riboside | [CAS]
2004-07-1 | [Synonyms]
2-AMINO-6-CHLORO-9-(BETA-D-RIBOFURANOSYL)PURINE
2-AMINO-6-CHLOROPURINE-9-BETA-D-RIBOSIDE
2-AMINO-6-CHLOROPURINE-9-RIBOSIDE
2-AMINO-6-CHLOROPURINE RIBOSIDE
6-CHLOROADENOSINE
6-CHLOROGUANINE RIBOSIDE
6-CHLOROGUANOSINE
6-chloro-9-beta-D-ribofuranosyl-9H-purin-2-amine
2-Amino-6-chloro-9H-purine-9-riboside
2-Amino-6-chloropurine-9-b-D-riboside
2-Amino-6-chloro-9-(b-D-ribofuranosyl)purine
6-Chloroguanosine2
2-AMINO-6-CHLOROPURINE RIBOSIDE 97% (HPLC)
2-AMINO-6-CHLOROPURINE RIBOSIDE (6-CHLOROGUANOSINE)
9H-PURIN-2-AMINE, 6-CHLORO-9-.BETA.-D-RIBOFURANOSYL-
2-Amino-6-chloropurine-9--D-riboside
6-Chloroguanine nucleoside
(-)-2-Amino-6-chloropurine riboside, 6-Chloroguanine riboside
1β-(2-Amino-6-chloro-9H-purine-9-yl)-1-deoxy-β-D-ribofuranose
2-Amino-6-chloro-9-β-D-ribofuranosyl-9H-purine | [EINECS(EC#)]
217-905-3 | [Molecular Formula]
C10H12ClN5O5 | [MDL Number]
MFCD00005735 | [Molecular Weight]
317.69 | [MOL File]
2004-07-1.mol |
| Chemical Properties | Back Directory | [Appearance]
Colourless Crystalline Solid | [Melting point ]
165-167 °C (dec.)(lit.) | [Boiling point ]
729.9±70.0 °C(Predicted) | [density ]
1.8359 (rough estimate) | [refractive index ]
-38 ° (C=0.1, H2O) | [storage temp. ]
−20°C
| [solubility ]
DMSO, Methanol | [form ]
Powder | [pka]
13.05±0.70(Predicted) | [color ]
White to Off-white | [InChIKey]
TXWHPSZYRUHEGT-ACJOCUEISA-N | [CAS DataBase Reference]
2004-07-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HS Code ]
29349990 |
| Hazard Information | Back Directory | [Chemical Properties]
Colourless Crystalline Solid | [Uses]
6-Substituted purines; a novel class of inhibitors of endogenous protein degradation | [References]
[1] A. JANKOWSKI L. T D Wise. Sodium Thiosulfate and Potassium Selenosulfate as Reagents to Prepare Thio-and Selenopurine Nucleosides[J]. Nucleosides, Nucleotides & Nucleic Acids, 1989, 8 1: 339-348. DOI:10.1080/07328318908054179.
[2] SUNDEEP RAYAT. 5-Cyanoimino-4-oxomethylene-4,5-dihydroimidazole and 5-Cyanoamino-4-imidazolecarboxylic Acid Intermediates in Nitrosative Guanosine Deamination: Evidence from 18O-Labeling Experiments[J]. Journal of the American Chemical Society, 2004, 126 32: 9960-9969. DOI:10.1021/ja049835q.
[3] MORRIS J. ROBINS. Nucleic acid related compounds. 114. Synthesis of 2,6-(disubstituted)purine 2′,3′-dideoxynucleosides and selected cytotoxic, anti-hepatitis b, and adenosine deaminase substrate activities[J]. Journal of Heterocyclic Chemistry, 2009, 38 6: 1297-1306. DOI:10.1002/jhet.5570380609.
[4] KATHLEEN TOO . Anti-malarial activity of N6-modified purine analogues[J]. Bioorganic & Medicinal Chemistry, 2007, 15 16: Pages 5551-5562. DOI:10.1016/j.bmc.2007.05.038.
[5] ALICJA STACHELSKA-WIERZCHOWSKA. Tri-Cyclic Nucleobase Analogs and their Ribosides as Substrates of Purine-Nucleoside Phosphorylases. II Guanine and Isoguanine Derivatives.[J]. Molecules, 2019, 24 8. DOI:10.3390/molecules24081493.
[6] SHIH-HSI CHU Ming Y C Chyng Yann Shiue. Synthesis and cytotoxicity of 6-selenopurine arabinoside and related compounds[J]. Journal of pharmaceutical sciences, 1975, 64 8: 1343-1346. DOI:10.1002/jps.2600640818. |
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