| Identification | More | [Name]
2,5-DICHLOROANISOLE | [CAS]
1984-58-3 | [Synonyms]
1,4-DICHLORO-2-METHOXYBENZENE
2,5-DICHLOROANISOLE
2,5-DICHLOROMETHOXYBENZENE
1,4-dichloro-2-methoxy-benzen
2,5-DICHLOROANISOLE 99%
Banair | [EINECS(EC#)]
217-852-6 | [Molecular Formula]
C7H6Cl2O | [MDL Number]
MFCD00061123 | [Molecular Weight]
177.03 | [MOL File]
1984-58-3.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/22:Harmful by inhalation and if swallowed . | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) . | [RIDADR ]
1993 | [Hazard Note ]
Irritant | [TSCA ]
Yes | [HS Code ]
29093090 |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless to very slightly yellow liquid | [Uses]
1,4-Dichloro-2-methoxybenzene is a useful reagent for organic synthesis. | [Synthesis]
1,2,4-Trichlorobenzene (TCB), 50 wt% aqueous NaOH and methanol were added to a pressure reactor at a molar ratio of 1.0:2.4:10. The reactor was sealed and heated to 190°C under stirring conditions and maintained at this temperature for 90 minutes. Continuous stirring was maintained during the reaction. Upon completion of the reaction, the reactor was cooled to room temperature using an ice water bath. The reaction mixture was transferred to a separatory funnel and acidified with 10% H2SO4 to a pH below 1.5. Subsequently, dichloromethane was extracted three times with an aqueous layer. The final yield of 2,5-dichlorophenol was 64.6%. The ratio of regioselectivity (2,5-dichlorophenol to 2,5-dichloroanisole/2,4-dichlorophenol to 2,4-dichloroanisole/3,4-dichlorophenol to 3,4-dichloroanisole) was 71.9:15.5:12.6 as analyzed by gas chromatography (GC). | [References]
[1] Patent: WO2015/49160, 2015, A1. Location in patent: Page/Page column 11
[2] Patent: WO2015/49360, 2015, A1. Location in patent: Page/Page column 14 |
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