| Identification | More | [Name]
Metrizoic acid | [CAS]
1949-45-7 | [Synonyms]
3-ACETAMIDO-5-(N-METHYLACETAMIDO)-2,4,6-TRIIODOBENZOIC ACID
METRIZOIC ACID
3-(acetylamino)-5-(acetylmethylamino)-2,4,6-triiodo-benzoicaci
3-acetamido-2,4,6-triiodo-5-(n-methylacetamido)-benzoicaci
metrizoate
3-acetamido-2,4,6-triiodo-5-N-methylacetamidobenzoic acid
3-(Acetylamino)-5-[acetyl methyl-amino)2,4,6-triiodobenzoic acid
Metrizoic
3-Acetylamino-5-(N-methylacetylamino)-2,4,6-triiodobenzoic acid
Triosil-280 | [EINECS(EC#)]
217-761-1 | [Molecular Formula]
C12H11I3N2O4 | [MDL Number]
MFCD00867964 | [Molecular Weight]
627.94 | [MOL File]
1949-45-7.mol |
| Safety Data | Back Directory | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RTECS ]
DG0887300 | [HS Code ]
2924.29.7790 |
| Hazard Information | Back Directory | [Originator]
Isopaque,Winthrop,France,1973 | [Uses]
Diagnosis aid (radiopaque medium). | [Definition]
ChEBI: Metrizoic acid is a monocarboxylic acid. It has a role as a radioopaque medium. | [Manufacturing Process]
3,5-Diacetamido-2,4,6-triiodobenzoic acid (diatrizoic acid) (see Diatrizoate entry for synthesis) (10 g) is suspended in water (10 ml), 5 N potassium
hydroxide (4.3 equivalent) is added and the mixture cooled to about 15°C.
Dimethyl sulfate (0.5 equivalent) dissolved in an equal volume of acetone is
added drop by drop while stirring. After the reaction mixture has been stirred
for about 1 hour hydrochloric acid (1:1) is added, with stirring to pH about
0.5. The precipitate is filtered, washed and suspended moist in 4 parts of
water, concentrated ammonia is added to pH about 7 and the ammonium salt
solution is isomerized at 90°C to 100°C for about one-half hour whereafter
additional ammonia is added to pH about 9 followed by solid ammonium
chloride (about 10% weight/volume) and the solution stirred overnight and
the excess of 3,5-diacetamide-2,4,6-triiodobenzoic acid recovered as
ammonium salt on the filter. The filtrate is precipitated by means of
hydrochloric acid (1:1 ) at pH about 0.5 and the N-methyl-3,5-diacetamido-
2,4,6-triiodobenzoic acid collected on a filter, washed and dried. | [Therapeutic Function]
Diagnostic aid (radiopaque medium) |
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