| Identification | More | [Name]
1-Methylindole-3-carboxaldehyde | [CAS]
19012-03-4 | [Synonyms]
1-METHYL-1H-INDOLE-3-CARBALDEHYDE
1-METHYL-1H-INDOLE-3-CARBOXALDEHYDE
1 METHYLINDOLE-3-ALDEHYDE
1-METHYLINDOLE-3-CARBALDEHYDE
1-METHYLINDOLE-3-CARBOXALDEHYDE
AKOS JY2082515
ASINEX-REAG BAS 12967420
RARECHEM AH BS 0121
TIMTEC-BB SBB010057
1H-Indole-3-carboxaldehyde, 1-methyl-(9CI)
3-formyl-1-methylindole
1-METHYLINDOLE-3-CARBOXALDEHYDE 98% (HPLC)
1-Methylindole-3-carboxaldehyde, 98+%
3-Formyl-1-methyl-1H-indole | [EINECS(EC#)]
242-750-3 | [Molecular Formula]
C10H9NO | [MDL Number]
MFCD00014570 | [Molecular Weight]
159.18 | [MOL File]
19012-03-4.mol |
| Chemical Properties | Back Directory | [Appearance]
light yellow to orange or brown crystalline powder | [Melting point ]
70-72 °C (lit.) | [Boiling point ]
186-189 °C(Press: 3-4 Torr) | [density ]
1.10±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
Crystalline Powder and Chunks | [color ]
Light yellow to orange or brown | [Water Solubility ]
Insoluble in water. | [Sensitive ]
Air Sensitive | [BRN ]
121302 | [CAS DataBase Reference]
19012-03-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [HazardClass ]
IRRITANT | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
light yellow to orange or brown crystalline powder | [Uses]
1-Methylindole-3-carboxaldehyde is used as a reactant for preparation of nitroolefins and β-nitroalcohols via microwave- or ultrasound-assisted Henry reactions, reactant for synthesis of quinolinones via three-component Ugi reaction, reactant for synthesis of α-ketoamides as inhibitors of Dengue virus protease with antiviral activity in cell-culture, reactant for preparation of thiazolopyrimidinones as inhibitors of Bcl-2 proteins, reactant for preparation of vinylindoles via Peterson olefination or olefination with Nysted reagent, reactant for preparation of indolyl alkenes from microwave-enhanced Knoevenagel condensation as antibacterial agents 1-Methylindole-3-carboxaldehyde may be used in the synthesis of (Z)-3-(1-methyl-1H-indol-3-yl)-2-(thiophen-3-yl)acrylonitrile, via base-catalyzed condensation with thiophene-3-acetonitrile. It was also used in the preparation of monomer, required for the synthesis of poly(3-vinyl-1-methylindole). | [Uses]
Reactant for preparation of nitroolefins and β-nitroalcohols via microwave- or ultrasound-assisted Henry reactions Reactant for synthesis of quinolinones via three-component Ugi reaction Reactant for synthesis of α-ketoamides as inhibitors of Dengue virus protease with antiviral activity in cell-culture Reactant for preparation of thiazolopyrimidinones as inhibitors of Bcl-2 proteins Reactant for preparation of vinylindoles via Peterson olefination or olefination with Nysted reagent Reactant for preparation of indolyl alkenes from microwave-enhanced Knoevenagel condensation as antibacterial agents. | [Synthesis Reference(s)]
Tetrahedron, 49, p. 4015, 1993 DOI: 10.1016/S0040-4020(01)89915-4
Synthesis, p. 396, 1987 DOI: 10.1055/s-1987-27960 | [General Description]
1-Methylindole-3-carboxaldehyde is a heterocyclic indole aldehyde. 1-Methylindole-3-carboxaldehyde on condensation with 2-hydroxybenzohydrazide yields Schiff base. |
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