1840886-10-3

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1840886-10-3 Structure

Identification	Back Directory
[Name] DBCO-PEG4-amine
[CAS] 1840886-10-3
[Synonyms] DBCO-PEG2-amine TFA salt DBCO-PEG4-amine TFA salt Dibenz[b,f]azocine-5(6H)-butanamide, N-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)-11,12-didehydro-γ-oxo-
[Molecular Formula] C29H37N3O6
[MOL File] 1840886-10-3.mol
[Molecular Weight] 523.63

Chemical Properties	Back Directory
[Boiling point ] 784.1±60.0 °C(Predicted)
[density ] 1.23±0.1 g/cm3(Predicted)
[solubility ] Soluble in DMSO, DCM, DMF
[form ] Viscous Liquid
[pka] 15.14±0.46(Predicted)
[color ] Light yellow to yellow
[InChIKey] NFJQULPXXATMFO-UHFFFAOYSA-N
[SMILES] C(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)(=O)CCC(=O)NCCOCCOCCOCCOCCN

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[Description]

DBCO-PEG4-amine is a PEG linker which contains DBCO and amine moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases the water solubility of the compound.

[Biological Activity]

DBCO-PEG4-amine is a PROTAC bridge and belongs to the PEG class. DBCO-PEG4-amine can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

[in vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[target]

Cleavable

PEGs

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