| Identification | Back Directory | [Name]
DBCO-PEG4-maleimide | [CAS]
1480516-75-3 | [Synonyms]
DBCO-dPEG??-MAL
DBCO-PEG4-maleimide
DBCO-NH-PEG4-Maleimide
Dibenzocyclooctyne-PEG4-maleimide
DBCO-PEG4-Maleimide,Dibenzocyclooctyne-PEG4-maleimide
1H-Pyrrole-1-propanamide, N-[19-(11,12-dihydrodibenz[b,f]azocin-5(6H)-yl)-15-oxo-3,6,9,12-tetraoxa-16-azanondec-1-yl]-2,5-dihydro-2,5-dioxo-
N-(3-(11,12-dihydrodibenzo[b,f]azocin-5(6H)-yl)propyl)-1-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)-3,6,9,12-tetraoxapentadecan-15-amide | [Molecular Formula]
C36H42N4O9 | [MDL Number]
MFCD22572659 | [MOL File]
1480516-75-3.mol | [Molecular Weight]
674.74 |
| Chemical Properties | Back Directory | [Boiling point ]
965.2±65.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Viscous liquid | [pka]
15.01±0.46(Predicted) | [color ]
Colorless to light yellow | [InChIKey]
VVFZXPZWVJMYPX-UHFFFAOYSA-N | [SMILES]
N1(CCC(NCCOCCOCCOCCOCCC(=O)NCCC(N2CC3=CC=CC=C3C#CC3=CC=CC=C23)=O)=O)C(=O)C=CC1=O |
| Hazard Information | Back Directory | [Description]
DBCO-PEG4-Maleimide is PEG linker containing a maleimide group and a DBCO moiety. The hydrophilic PEG spacer arm improves solubility in aqueous buffers. Maleimide group specifically and efficiently reacts with thiols to form stable thioether bonds. The low mass weight will add minimal spacer to modified molecules and will enable simple and efficient incorporation of DBCO moiety onto cysteine-containing peptides or other thiol-containing biomolecules. DBCO is commonly used for copper-free Click Chemistry reactions. | [Uses]
Maleimide functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into thiol containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage. The PEG lipophilic spacer helps to reduce aggregation and precipitation problems when labeling biomolecules.
Applications Include:
- Protein-peptide conjugates
- Antibody-enzyme or antibody-drug conjugates
- Protein or peptide-oligonucleotide conjugates
- Surface modification
| [reaction suitability]
reaction type: click chemistry
reagent type: cross-linking reagent | [IC 50]
Non-cleavable Linker |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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