| Identification | Back Directory | [Name]
SRI 31215 | [CAS]
1832686-44-8 | [Synonyms]
SRI 31215
SRI31215 2TFA
SRI-31215 2TFA
SRI 31215 2TFA
SRI-31215 Bis-TFA salt
SRI31215 2TFA; SRI-31215 2TFA; SRI 31215 2TFA; SRI-31215 BIS-TFA SALT; SRI 31215 BIS-TFA SALT; SRI31215 BIS-TFA SALT | [Molecular Formula]
C27H34F3N5O3 | [MDL Number]
MFCD32062765 | [MOL File]
1832686-44-8.mol | [Molecular Weight]
533.6 |
| Hazard Information | Back Directory | [Uses]
SRI 31215 (TFA) is a Matriptase/Hepsin/hepatocyte growth factor activator (HGFA) triplex inhibitor and mimics the activity of HAI-1/2 (endogenous inhibitors of HGF activation). SRI 31215 has potent inhibitory activity against matriptase, hepsin and HGFA with IC50 values of 0.69 μM, 0.65 μM and 0.30 μM, respectively. SRI 31215 can be used for the research of cancer[1]. | [storage]
Store at -20°C | [References]
[1] Owusu BY, et al. Inhibition of pro-HGF activation by SRI31215, a novel approach to block oncogenic HGF/MET signaling. Oncotarget. 2016 May 17;7(20):29492-506. DOI:10.18632/oncotarget.8785 |
|
|