| Identification | More | [Name]
3,20-Dioxopregn-4-en-17-beta-yl acetate | [CAS]
17308-02-0 | [Synonyms]
17A-ACETOXYPROGESTERONE
17-ACETOXYPROGESTERONE
17a-hydroxy-4-pregnene-3,20-dione acetate
17A-HYDROXY PROGESTERONE ACETATE
17ALPHA-ACETOXY-4-PREGNENE-3,20-DIONE
17ALPHA-ACETOXYPROGESTERONE
17ALPHA-HYDROXY-4-PREGNENE-3,20-DIONE 17-ACETATE
17-ALPHA-HYDROXYPROGESTERONE 17-ACETATE
17ALPHA-HYDROXYPROGESTERONE ACETATE
17-HYDROXYPROGESTERONE ACETATE
4-PREGNEN-17ALPHA-OL-3,20-DIONE 17-ACETATE
4-PREGNEN-17ALPHA-OL-3,20-DIONE ACETATE
4-PREGNEN-17-OL-3,20-DIONE ACETATE
ACETIC ACID (8R,9S,10R,13S,14S,17R)-17-ACETYL-10,13-DIMETHYL-3-OXO-2,3,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL ESTER
HYDROXYPROGESTERONE ACETATE
Acetoxypro
17-Hydroxypregn-4-ene-3,20-dione 17-acetate
Pregn-4-en-17-ol-3,20-dione 17-acetate
17-(Acetyloxy)-pregn-4-ene-3,20-dione
17-Hydroxypregn-4-ene-3,20-dione acetate | [EINECS(EC#)]
206-119-6 | [Molecular Formula]
C23H32O4 | [MDL Number]
MFCD00021156 | [Molecular Weight]
372.5 | [MOL File]
17308-02-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
198 °C | [Boiling point ]
490.2±45.0 °C(Predicted) | [density ]
1.14±0.1 g/cm3(Predicted) | [InChI]
InChI=1/C23H32O4/c1-14(24)23(27-15(2)25)12-9-20-18-6-5-16-13-17(26)7-10-21(16,3)19(18)8-11-22(20,23)4/h13,18-20H,5-12H2,1-4H3/t18-,19+,20+,21+,22+,23-/s3 | [InChIKey]
VTHUYJIXSMGYOQ-NCZDLRRGNA-N | [SMILES]
O([C@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)C(=O)C)C(=O)C |&1:1,4,6,16,18,22,r| | [CAS DataBase Reference]
17308-02-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R40:Limited evidence of a carcinogenic effect.
R48:Danger of serious damage to health by prolonged exposure. | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2811 6.1/PG 2
| [WGK Germany ]
3
| [RTECS ]
TU5074000
|
| Hazard Information | Back Directory | [Uses]
3,20-Dioxopregn-4-en-17-beta-yl acetate, also known as 17-Hydroxyprogesterone acetate, is a new steroid
for oral administration. It has a progestational activity
which is at least twice that of anhydrohydroxyprogesterone[1]. | [Mechanism of action]
3,20-Dioxopregn-4-en-17-beta-yl acetate could induces secretory changes in the endometrium and luteal changes in the exfoliated vaginal epithelial cells, reduces fern-like patterns of the cervical mucus, causes a rise of basal body temperature, and induces withdrawal bleeding in castrates[1]. | [References]
[1] Davis M, et al. 17-α-HYDROXYPROGESTERONE ACETATE; AN EFFECTIVE PROGESTATIONAL SUBSTANCE ON ORAL ADMINISTRATION. The Journal of clinical endocrinology and metabolism, 1957; 17: 1237–1244,. |
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