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ChemicalBook--->CAS DataBase List--->149231-66-3

149231-66-3

149231-66-3 Structure

149231-66-3 Structure
IdentificationBack Directory
[Name]

AC-YVAD-PNA
[CAS]

149231-66-3
[Synonyms]

AC-YVAD-PNA
ACETYL-YVAD-PNA
ICE SUBSTRATE IV
Caspase-1 Substrate IV
AC-TYR-VAL-ALA-ASP-PNA
REF DUPL: Ac-Tyr-Val-Ala-Asp-pNA
CASPASE-1 SUBSTRATE (CHROMOGENIC)
AC-TYR-VAL-ALA-ASP-PNA: AC-YVAD-PNA
AC-TYR-VAL-ALA-ASP-PARANITROANILIDE
CASPASE-1 SUBSTRATE IV, COLORIMETRIC
IL-1B CONVERTING ENZYME SUBSTRATE IV
ACETYL-TYR-VAL-ALA-ASP-(P-NITROANILIDE)
N-acetyl-tyr-val-ala-asp P-nitroanilide
CASPASE 1 (ICE) SUBSTRATE 2, CHROMOGENIC
N-ACETYL-TYR-VAL-ALA-ASP-P-NITROANILIDE PNA
IL-1BETA CONVERTING ENZYME (ICE) COLORIMETRIC SUBSTRATE
N-Acetyl-L-tyrosyl-L-valyl-L-alanyl-N-(4-nitrophenyl)-L-α-asparagine
N-Acetyl-L-tyrosyl-L-valyl-L-alanyl-N-(4-nitrophenyl)-L-a-asparagine
L-α-Asparagine, N-acetyl-L-tyrosyl-L-valyl-L-alanyl-N-(4-nitrophenyl)-
[Molecular Formula]

C29H36N6O10
[MDL Number]

MFCD00274387
[MOL File]

149231-66-3.mol
[Molecular Weight]

628.63
Chemical PropertiesBack Directory
[Boiling point ]

1108.9±65.0 °C(Predicted)
[density ]

1.362±0.06 g/cm3(Predicted)
[storage temp. ]

-15°C
[form ]

powder
[pka]

4.04±0.10(Predicted)
[color ]

white to beige
Hazard InformationBack Directory
[Uses]

N-Acetyl-L-tyrosyl-L-valyl-L-alanyl-N-(4-nitrophenyl)-L-α-asparagine is a substrate whose amino acids YVAD have been shown to be a preferred cleavage site for caspase-1 and -4.
[Biological Activity]

Ac-YVAD-pNA is a very selective chromogenic substrate for caspase-1a key mediator of inflammatory processes formerly known as interleukin (IL)-1-converting enzyme. Ac-YVAD-pNA is used to determine caspase-1 activity. Cleavage of Ac-YVAD-pNA by caspase-1 releases pNA (p-nitroanilide)which can be quantified spectrophotometrically at 405 nm.
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