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ChemicalBook--->CAS DataBase List--->153088-73-4

153088-73-4

153088-73-4 Structure

153088-73-4 Structure
IdentificationBack Directory
[Name]

Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE
[CAS]

153088-73-4
[Synonyms]

Z-D-CH2-DCB
Z-ASP-CH2-DCB
ICE INHIBITOR V
ICE INHIBITOR VI
CASPASE-1 INHIBITOR V
CASPASE-1 INHIBITOR III
Z-ASP-[(2,6-DICHLOROBENZOYL)OXY]METHANE
Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE
N-CBZ-L-ASPARTIC ACID A-(2 6-DICHLORO- &
Z-L-ASP-ALPHA-[(2,6-DICHLOROBENZOYL)OXY]METHANE
N-cbz-L-aspartic acid A-(2,6-dichloro-*benzoyloxy
INTERLEUKIN-1BETA CONVERTING ENZYME INHIBITOR III
Z-L-Asp α-([2,6-dichlorobenzoyloxy]methyl ketone)
N-CBZ-L-aspartic acid alpha-[(2,6-dichlorobenzoyloxy)....
CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE
(BENZYLOXYCARBONYL-L-ASPART-1-YL)[(2,6-DICHLOROBENZOYL)OXY]METHANE
Benzoic acid, 2,6-dichloro-, (3S)-4-carboxy-2-oxo-3-[[(phenylmethoxy)carbonyl]amino]butyl ester
[Molecular Formula]

C20H17Cl2NO7
[MDL Number]

MFCD00674885
[MOL File]

153088-73-4.mol
[Molecular Weight]

454.26
Chemical PropertiesBack Directory
[storage temp. ]

−20°C
[solubility ]

Soluble in DMSO (up to 25 mg/ml).
[form ]

White to off-white powder.
[color ]

white
[Stability:]

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

Z-Asp-CH2-DCB is a peptide originally synthesized for its ability to inactivate the interleukin-1β-converting enzyme, which is the homolog of the C. elegans positive regulator of apoptosis CED-3. Z-Asp-CH2-DCB has been shown to block apoptosis by nonselectively inhibiting caspase activity. At 1-100 μM, it can dose-dependently block the production of IL-1β, TNF-α, IL-6, and IFN-γ by human peripheral blood mononuclear cells as well as inhibit T cell proliferation.
[Uses]

Z-Asp-2,6-dichlorobenzoyloxymethylketone is a broad Caspase Inhibitor.
[References]

1) Dolle et al. (1994) P1 aspartate-based peptide alpha-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1 beta-converting enzyme; J.Med.Chem. 37 563
Spectrum DetailBack Directory
[Spectrum Detail]

Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE(153088-73-4)1HNMR
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