Identification | More | [Name]
Chelidamic acid | [CAS]
138-60-3 | [Synonyms]
1,4-DIHYDRO-4-OXO-2,6-PYRIDINEDICARBOXYLIC ACID 4-HYDROXY-2,6-PYRIDINEDICARBOXYLIC ACID 4-HYDROXYPYRIDINE-2,6-DICARBOXYLIC ACID 4-PYRIDONE-2,6-DICARBOXYLIC ACID AKOS 90653 CHELIDAMIC ACID CHELIDAMIC ACID HYDRATE 1,4-Dihydro-4-oxo-2,6-pyridinedicarboxylic acid hydrate 4-Hydroxypyridine-2,6-dicarboxylic acid hydrate chelidamic acid approx. 95% Chelidamic aicd 1,4-dihydro-4-oxopyridine-2,6-dicarboxylic acid .HELIDAMIC AICD 4-Hydroxy-2,6-pyridenedicarboxylic acid Ammox-chelidonic acid 4-Oxo-1,4-dihydro-2,6-pyridinedicarboxylic acid Chelidamic acid (4-Hydroxypyridine-2,6-dicarboxylic acid) 1,4-Dihydro-4-oxo-2,6-pyridinedicarboxylic acid hydrate, 4-Hydroxypyridine-2,6-dicarboxylic acid 2,6-Pyridinedicarboxylic acid, 1,4-dihydro-4-oxo- 4-Oxo-1H-pyridine-2,6-dicarboxylic acid | [EINECS(EC#)]
205-335-8 | [Molecular Formula]
C7H5NO5 | [MDL Number]
MFCD00066478 | [Molecular Weight]
183.12 | [MOL File]
138-60-3.mol |
Chemical Properties | Back Directory | [Melting point ]
265-270 °C | [Boiling point ]
428.3±45.0 °C(Predicted) | [density ]
1.726±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
1 M NH4OH: 50mg/mL, clear to slightly hazy | [form ]
powder | [pka]
0.12±0.40(Predicted) | [color ]
brown | [biological source]
synthetic (organic) | [Detection Methods]
HPLC,NMR | [BRN ]
476229 | [InChI]
InChI=1S/C7H5NO5/c9-3-1-4(6(10)11)8-5(2-3)7(12)13/h1-2H,(H,8,9)(H,10,11)(H,12,13) | [InChIKey]
XTLJJHGQACAZMS-UHFFFAOYSA-N | [SMILES]
C1(C(O)=O)NC(C(O)=O)=CC(=O)C=1 | [CAS DataBase Reference]
138-60-3(CAS DataBase Reference) |
Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [HS Code ]
29333990 |
Hazard Information | Back Directory | [Chemical Properties]
Light yellow powder | [Uses]
Chelidamic acid hydrate has been used in eluent solution as a complexing additive in high-performance chelation ion chromatography (HPCIC) for speciation of iron. It has also been used as an organic ligand for the polyoxometalate (POM)-based lanthanoid hybrid compounds. | [Biochem/physiol Actions]
Among the most potent of the tested "conformationally restricted glutamate analogs" as an inhibitor of glutamate decarboxylase. | [Synthesis]
4-Oxo-1,4-dihydro-2,6-pyridinedicarboxylic acid was synthesized from betulinic acid using a modified literature method. The specific operation was as follows: 425 mL of 30% ammonia solution (containing NH3 41.8 g, 0.21 mol) was slowly added dropwise to the reaction system at 0 °C, and the dropwise addition process was controlled to be completed within 1 hour. After the dropwise addition, the reaction mixture was stirred continuously at room temperature for 48 hours. Upon completion of the reaction, the excess ammonia solution was removed by distillation under reduced pressure. Subsequently, the residue was mixed with 50 mL of water, activated carbon was added and decolorized by refluxing for 15 minutes. After hot filtration, the filtrate was collected and, after being cooled to room temperature, the pH was adjusted with a 37% aqueous hydrochloric acid solution to 1. At this point, a white solid precipitated from the solution, which was collected by filtration, washed several times with cold water, and finally dried under vacuum for 16 h. The target compound, 4-oxo-1,4-dihydro-2,6-pyridinedicarboxylic acid (13), was obtained as a white solid in a yield of 42 g with 98% yield. | [Advantages]
Chelidamic acid (1,4-dihydro-4-oxopyridine-2,6- dicarboxylic acid, CDA) is an organic material with great potential for accepting alkaline ions. It could be used as the anode material in LIBs. The new materials offer high capacity, superior cycle retention, favourable rate capability, and interesting electrochemical behaviours[1]. | [References]
[1] Fu-Ming Wang*. “Synthesis and Characterization of Chelidonic Acid and Chelidamic Acid as Organic Anode Materials for Energy Storage.” ACS Sustainable Chemistry & Engineering 9 36 (2021): 12286–12299.
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