| Identification | Back Directory | [Name]
BISINDOLYLMALEIMIDE II | [CAS]
137592-45-1 | [Synonyms]
BISINDOLYLMALEIMIDE II
2-[1-[2-(1-METHYLPYRROLIDINO)ETHYL]-1H-INDOL-3-YL]-3-(1H-INDOL-3-YL)MALEIMIDE
3-(1H-indol-3-yl)-4-[1-[2-(1-methylpyrrolidin-2-yl)ethyl]indol-3-yl]pyrrole-2,5-dione
3-(1H-Indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione | [Molecular Formula]
C27H26N4O2 | [MDL Number]
MFCD00236430 | [MOL File]
137592-45-1.mol | [Molecular Weight]
438.52 |
| Chemical Properties | Back Directory | [Boiling point ]
709.9±60.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
DMSO: soluble | [form ]
solid | [pka]
8.17±0.60(Predicted) | [color ]
Yellow to orange | [biological source]
synthetic (organic) |
| Hazard Information | Back Directory | [Uses]
Bisindolylmaleimide II, is a potent ATP-competitive protein kinase C (PKC) inhibitor. In addition it inhibits PDK1 (IC50 = 14 μM), an important kinase in the insulin signaling pathway, and PKA (IC50 = 2.94 μM). | [Biological Activity]
Bisindolylmaleimide II (BIS II) acts as a dual protein kinase A/C (PKA/C) inhibitor. | [storage]
Store at -20°C |
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