| Identification | More | [Name]
N-(Trimethylsilyl)acetamide | [CAS]
13435-12-6 | [Synonyms]
N-TRIMETHYLSILYLACETAMIDE
TMSA
TMS ACETAMIDE
TRIMETHYLSILYLACETAMIDE
(acetylamino)trimethylsilane
n-(trimethylsilyl)-acetamid
N-TrimethylsilylacetamideA.R.
Acetamide, N-(trimethylsilyl)-
trimethylsilyl
N-TRIMETHYLSILYL ACETAMIDE(TMSA)
N-TMS-acetamide | [EINECS(EC#)]
236-565-7 | [Molecular Formula]
C5H13NOSi | [MDL Number]
MFCD00008671 | [Molecular Weight]
131.25 | [MOL File]
13435-12-6.mol |
| Chemical Properties | Back Directory | [Appearance]
WHITE TO YELLOWISH CRYSTALLINE MASS | [Melting point ]
46-49 °C(lit.)
| [Boiling point ]
84 °C18 mm Hg(lit.)
| [density ]
0.859±0.06 g/cm3(Predicted) | [Fp ]
135 °F
| [storage temp. ]
Flammables area | [solubility ]
Chloroform, DMSO, Methanol | [form ]
Crystalline Mass | [pka]
18.23±0.46(Predicted) | [color ]
White to yellow | [Water Solubility ]
reacts | [Hydrolytic Sensitivity]
7: reacts slowly with moisture/water | [Sensitive ]
Moisture Sensitive | [BRN ]
741928 | [Stability:]
Moisture Sensitive | [CAS DataBase Reference]
13435-12-6(CAS DataBase Reference) | [EPA Substance Registry System]
13435-12-6(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi-F | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R11:Highly Flammable. | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
1325 | [WGK Germany ]
3
| [RTECS ]
AD0250000
| [F ]
10-21 | [TSCA ]
Yes | [HazardClass ]
4.1 | [PackingGroup ]
III | [HS Code ]
29319090 |
| Hazard Information | Back Directory | [Chemical Properties]
WHITE TO YELLOWISH CRYSTALLINE MASS | [Uses]
N-Trimethylsilylacetamide is a silylating agent used in organic synthesis. N-Trimethylsilylacetamide is used in the preparation of the antibacterial agent Cefdinir (C242670). | [General Description]
The efficiency of N-(Trimethylsilyl)acetamide (TMS acetamide) as allyl group scavenger and its compatibility with Fluorenylmethyloxycarbonyl chloride (Fmoc) protecting groups were studied. | [Purification Methods]
Distil the amide repeatedly in an inert atmosphere with all operations to be performed in an anhydrous atmosphere. In the presence of moisture, trimethylsilanol (b 31-34o/26mm) is formed and is a likely impurity (check by NMR). [Birkofer et al. Chem Ber 96 1473 1963, Beilstein 4 IV 4011.] |
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