| Identification | More | [Name]
Perospirone hydrochloride | [CAS]
129273-38-7 | [Synonyms]
(3ar,7as)-2-[4-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]butyl]-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione hydrochloride
PEROSPIRONE HYDROCHLORIDE
PEROSPIRONE HYDROCHLORIDE DIHYDRATE
PEROSPIRONE HYDROCHLORIDE HYDRATE
1h-isoindole-1,3(2h)-dione,2-(4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)but
monohydrochloride,cis-yl)hexahydro
sm-9018
(3aR,7aS)-rel-2-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-1H- isoindole-1,3(2H)-dione Hydrochloride Trihydrate
Lulla
Perospirone Hydrochloride Trihydrate
(3aR,7aS)-2-[4-[4-(1,2-Benzothiazol-3-yl)piperazin-1-yl]butyl]-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione hydrochloride
Lullan | [Molecular Formula]
C23H35ClN4O4S | [MDL Number]
MFCD08457543 | [Molecular Weight]
499.07 | [MOL File]
129273-38-7.mol |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
95-970C | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Usage]
Serotonin (5-HT2) and dopamine (D2) antagonist (SDA) | [InChIKey]
HIZFAPMOZFYELI-GNXQHMNLNA-N | [SMILES]
C(N1CCN(C2=NSC3C=CC=CC2=3)CC1)CCCN1C([C@@]2([H])CCCC[C@@]2([H])C1=O)=O.Cl |&1:21,27,r| | [CAS DataBase Reference]
129273-38-7(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Serotonin (5-HT2) and dopamine (D2) antagonist (SDA) | [Biological Activity]
Perospirone (SM-9018) is a typical neuroleptic (antipsychotic) agent th at displays high affinity for 5-HT2D2 and 5-HT1A receptors (Ki = 0.611.4 and 2.9-1.8 nMrespectively)moderate affinity for alpha 1 and D1 receptors (Ki = 17 and 41 nMrespectively)while exhibiting much reduced affinity for alpha 2 (Ki = 408 nM) and little affinity toward muscarinicopiateglutamatephencyclidinebenzodiazepine or GABAA receptors (Ki >1 μM). SM-9018 antagonizes both D2-dependent (e.g. methamphetamine-induced hyperactivityapomorphine-induced stereotypy) and 5-HT2-mediated (e.g. tryptamine-induced clonic seizure) activities in vivowhile exhibiting very low cataleptogenic and central depressant activities commonly observed with two other neurolepticshaloperidol and chlorpromazine. | [IC 50]
5-HT2A Receptor: 0.6 nM (Ki); D2 Receptor: 1.4 nM (Ki); 5-HT1A Receptor: 2.9 nM (Ki); 5-HT1 Receptor: 18 nM (Ki); D1 Receptor: 41 nM (Ki) |
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