| Identification | More | [Name]
ACETONYLTRIPHENYLPHOSPHONIUM CHLORIDE | [CAS]
1235-21-8 | [Synonyms]
(2-OXOPROPYL)-TRIPHENYLPHOSPHONIUM CHLORIDE
ACETONYLTRIPHENYLPHOSPHONIUM CHLORIDE
AURORA KA-1148
acetonyltriphenyl-phosphoniuchloride
ACETONYLTRIPHENYLPHOSPHONIUM CHLORIDE, 9 8% | [EINECS(EC#)]
214-974-1 | [Molecular Formula]
C21H20ClOP | [MDL Number]
MFCD00011813 | [Molecular Weight]
354.81 | [MOL File]
1235-21-8.mol |
| Chemical Properties | Back Directory | [Appearance]
WHITE TO SLIGHTLY BEIGE FINE CRYSTALLINE POWDER | [Melting point ]
243-245 °C(lit.) | [storage temp. ]
Store below +30°C. | [form ]
solid | [color ]
White to Light yellow to Light orange | [Water Solubility ]
Soluble in hot water. | [Sensitive ]
Hygroscopic | [CAS DataBase Reference]
1235-21-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [RTECS ]
TA1841000
| [F ]
3 | [HS Code ]
29319019 | [Toxicity]
mouse,LD50,intravenous,56mg/kg (56mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#01535, |
| Hazard Information | Back Directory | [Chemical Properties]
WHITE TO SLIGHTLY BEIGE FINE CRYSTALLINE POWDER | [Uses]
Used to investigate the antimycobacterial activities of Me alkenyl quinolones
Reactant for synthesis of:
- Unsaturated esters and ketones containing multiple aromatic and heteroaromatic rings using Suzuki coupling - Wittig olefination
- Fused oxygen and nitrogen heterocycles via regioselective cyclocondensation
Reactant for Wittig olefinations | [Uses]
Acetonyltriphenylphosphonium chloride is used to investigate the antimycobacterial activities of Me alkenyl quinolones. It is used as a reactant for synthesis of unsaturated esters and ketones containing multiple aromatic and heteroaromatic rings using Suzuki coupling - Wittig olefination. | [reaction suitability]
reaction type: C-C Bond Formation | [Purification Methods]
Recrystallise it from CHCl3/*C6H6/pet ether (b 60-80o) or by dissolving it in CHCl3 and pouring it into dry Et2O. max nm() 255(3,600), 262(3,700), 268(4,000) and 275(3,100). The iodide salt crystallises from H2O and has m 207-209o. [Ramirez & Dershowitz J Org Chem 22 41 1957.] Itisan IRRITANT and is hygroscopic. When shaken with a 10% aqueous solution of Na2CO3 (8hours) it gives acetylmethylene triphenyl phosphorane which is recrystallised from MeOH/H2O and after drying at 70o/0.1mm has m 205-206o. UV: nm() 268 (6600), 275 (6500) and 288 (5700), IR: max 1529 (s), 1470 (m), 1425 (s), max 1374 (m), 1105 and 978 (s) (cm-1). [Ramirez & Dershowitz J Org Chem 22 41, 44 1957, Beilstein 16 H 761, 16 II 373.] |
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