| Identification | Back Directory | [Name]
10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE | [CAS]
122955-42-4 | [Synonyms]
XE 991
XE9912HCl
XE 991 DIHYDROCHLORIDE
9(10H)-Anthracenone, 10,10-bis(4-pyridinylmethyl)-
10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride
10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE | [Molecular Formula]
C26H20N2O | [MDL Number]
MFCD05662331 | [MOL File]
122955-42-4.mol | [Molecular Weight]
376.45 |
| Chemical Properties | Back Directory | [Melting point ]
231-232 °C | [Boiling point ]
585.0±38.0 °C(Predicted) | [density ]
1.238±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: >20mg/mL | [form ]
solid | [pka]
6.08±0.10(Predicted) | [color ]
white to beige | [Water Solubility ]
Soluble in water (100mM) |
| Hazard Information | Back Directory | [Uses]
XE-991 has been used as a KCNQ (Kv7.2/7.3) inhibitor to examine whether M-current inhibition affects oxytocin receptor (TGOT) mediated depolarization. It has also been used as an KCNQ inhibitor to study the ionic mechanism responsible for the overshoot/undershoot in membrane potential in mouse cholinergic interneurons (ChIs) in the presence of tetrodotoxin (TTX). | [Biological Activity]
Potent and selective blocker of KCNQ voltage-gated potassium channels. Blocks KCNQ2+3/M-currents (IC 50 = 0.6-0.98 μ M) and KCNQ1 homomeric channels (IC 50 = 0.75 μ M) but is less potent against KCNQ1/minK channels (IC 50 = 11.1 μ M). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo . | [Biochem/physiol Actions]
XE-991 is a KCNQ channel blocker; which is more potent than linopiridine (Cat. No. L-134). | [storage]
Room temperature (desiccate) |
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