| Identification | More | [Name]
2-Methoxypropene | [CAS]
116-11-0 | [Synonyms]
2-METHOXY-1-PROPENE
2-METHOXYPROPENE
ISOPROPENYL METHYL ETHER
Methyl isopropenyl ether
MOP
1-Propene,2-methoxy-
2-methoxy-1-propen
2-methoxy-prop-1-ene
2-methoxyprop-1-ene
2-methoxy-propen
CH2=C(CH3)OCH3
Ether, isopropenyl methyl
ether,isopropenylmethyl
2-METHOXYPROPENE, STAB.
2-METHYOXYPROPENE
2-Methoxypropene, stabilized, 98%
2-METHOXYPROPENE , STABILIZED WITH CA 0.5% POTASSIUM CARBONATE
2-METHOXYPROPENE, 99.5+%
2-METHOXYPROPENE:ISOPROPENYL METHYL ETHER 99%
2-Methoxypropene, 98%, stab. with ca 0.5% potassium carbonate | [EINECS(EC#)]
204-125-3 | [Molecular Formula]
C4H8O | [MDL Number]
MFCD00014929 | [Molecular Weight]
72.11 | [MOL File]
116-11-0.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colorless liquid | [Melting point ]
25°C | [Boiling point ]
34-36 °C (lit.) | [density ]
0.766 g/mL at 20 °C
| [vapor pressure ]
27.96 psi ( 55 °C)
| [refractive index ]
n20/D 1.382(lit.)
| [Fp ]
−21 °F
| [storage temp. ]
2-8°C
| [solubility ]
Chloroform | [form ]
Liquid | [color ]
Clear colorless | [PH]
7 (H2O) | [Water Solubility ]
negligible | [Sensitive ]
Light Sensitive | [Detection Methods]
GC | [BRN ]
1734635 | [LogP]
1.7 at 21℃ and pH8.1-8.4 | [CAS DataBase Reference]
116-11-0(CAS DataBase Reference) | [NIST Chemistry Reference]
1-Propene, 2-methoxy-(116-11-0) | [EPA Substance Registry System]
116-11-0(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
F+,Xn | [Risk Statements ]
R12:Extremely Flammable.
R19:May form explosive peroxides.
R22:Harmful if swallowed. | [Safety Statements ]
S3:Keep in a cool place .
S16:Keep away from sources of ignition-No smoking .
S29:Do not empty into drains .
S33:Take precautionary measures against static discharges .
S7/9:Keep container tightly closed and in a well-ventilated place .
S9:Keep container in a well-ventilated place .
S18:Handle and open container with care . | [RIDADR ]
UN 1993 3/PG 1
| [WGK Germany ]
1
| [RTECS ]
UD0800000
| [F ]
8-10 | [Autoignition Temperature]
374 °F | [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
I | [HS Code ]
29091990 | [Hazardous Substances Data]
116-11-0(Hazardous Substances Data) | [Toxicity]
rabbit,LD50,skin,> 20mL/kg (20mL/kg),American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969. |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless liquid | [Uses]
2-Methoxypropene is used in the synthesis of Macrolactin A, a 24-member macrolide typically employed as an antibiotic. Also used in the synthesis of phenylalanine derivatives used as α4β1 and α4β7 receptor antagonists in the treatment of allergic asthma. | [Preparation]
2-Methoxypropene is prepared in high yield from Succinic Anhydride, 2,2-Dimethoxypropane, benzoic acid, and Pyridine.
| [Reactivity Profile]
2-Methoxypropene is an electron-rich alkene used in the monoprotection of aliphatic, allylic, and propargylic alcohols, often followed by Claisen or other rearrangements; protection of peroxides, cyanohydrins, α-hydroxy ketones, and phenols; condensation with amines; protection of 1,2- and 1,3-diols, sometimes followed by Prins rearrangements; protection of 1,2-dithiols and α-hydroxy carbamates; participant in pericyclic reactions; formation of 2-methoxyallyl halides and substituted furans.
| [Toxics Screening Level]
The initial threshold screening level (ITSL) for 2-Methoxy-1-propene is 6 μg/m3 based on an annual averaging time. | [Precautions]
flammable liquid; light-sensitive; should be refrigerated.
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