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ChemicalBook--->CAS DataBase List--->112885-41-3

112885-41-3

112885-41-3 Structure

112885-41-3 Structure
IdentificationMore
[Name]

4-Amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)-2-morpholinyl)methyl)benzamide
[CAS]

112885-41-3
[Synonyms]

4-AMINO-5-CHLORO-2-ETHOXY-N-((4-(4-FLUOROBENZYL)-2-MORPHOLINYL)METHYL)BENZAMIDE
4-AMINO-5-CHLORO-2-ETHOXY-N-[4-(4-FLUORO-BENZYL)-MORPHOLIN-2-YLMETHYL]-BENZAMIDE
4-AMINO-5-CHLORO-2-ETHOXY-N-[[[4-(4-FLUOROPHENYL)METHYL]-2-MORPHOLINYL]METHYL]-BENZAMIDE
MOSAPRIDE
((4-(4-fluorobenzyl)-2-morpholinyl)methyl)benzamide/mosapride
4-Amino-5-Chloro-2-Ethoxy-N-((4-(4-Fluorobenzyl)-2-Morpholinyl)Methyl)Benzamide/Mosapride
[Molecular Formula]

C21H25ClFN3O3
[MDL Number]

MFCD00867430
[Molecular Weight]

421.89
[MOL File]

112885-41-3.mol
Chemical PropertiesBack Directory
[Appearance]

White to Off-White Crystalline Solid
[Melting point ]

151-153°C
[Boiling point ]

549.2±50.0 °C(Predicted)
[density ]

1.272±0.06 g/cm3(Predicted)
[storage temp. ]

Keep in dark place,Sealed in dry,Room Temperature
[solubility ]

DMSO (Slightly), Methanol (Slightly)
[form ]

Solid
[pka]

13.52±0.46(Predicted)
[color ]

White to Off-White
[Usage]

a selective 5-HT4 receptor agonist
[CAS DataBase Reference]

112885-41-3(CAS DataBase Reference)
Hazard InformationBack Directory
[Hazard]

A poison by ingestion.
[Description]

Mosapride citrate, a new gastroprokinetic benzamide was introduced in Japan as Gasmotin for the relief of gastrointestinal symptoms in patients with chronic gastritis, gastro-oesophageal reflux, dyspepsia and post-surgery use. Mosapride is synthesized by final amidation between the corresponding benzoic acid, itself obtained in 3 steps from methyl 4-acetamido salicylate, and the appropriate 2-aminomethyl-morpholine. Mosapride is a 5-HT4 partial agonist without notable activity for D2, 5-HT1 , 5-HT2, alpha-1 and alpha-2 receptors. In dogs, mosapride was as potent as cisapride to stimulate antral and duodenal motility. In most of species including man, mosapride undergoes extensive cleavage to a N-debenzylated metabolite which retains partial 5-HT4 activity but has potent 5-HT3 antagonist activity.
[Chemical Properties]

White to Off-White Crystalline Solid
[Originator]

Dainippon (Japan)
[Uses]

A selective 5-HT4 receptor agonist. Gastroprokinetic.
[Uses]

gastroprokinetic agent
[Definition]

ChEBI: Mosapride is a racemate comprising equimolar amounts of (R)- and (S)-mosapride. It is a gastroprokinetic agent which acts on 5-hydroxytryptamine type 4 (5-HT4) receptors in the gastrointestinal plexus, consequently increasing the release of acetylcholine and hence enhancing gastrointestinal motility and gastric emptying. It has a role as a gastrointestinal drug and a serotonergic agonist. It contains a (R)-mosapride and a (S)-mosapride.
[Brand name]

Gasmotin
[storage]

Store at -20°C
Safety DataBack Directory
[Safety Profile]

A poison by ingestion. When heated to decomposition it emits toxic vapors of NOx, F-, and Cl-.
Spectrum DetailBack Directory
[Spectrum Detail]

Mosapride(112885-41-3)MS
Mosapride(112885-41-3)1HNMR
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

112885-41-3(sigmaaldrich)
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