| Identification | More | [Name]
BOC-TRANS-4-AMINOCYCLOHEXANOL | [CAS]
111300-06-2 | [Synonyms]
BOC-TRANS-4-AMINOCYCLOHEXANOL
N-T-BOC-TRANS-4-AMINO CYCLOHEXANOL
TERT-BUTYL TRANS-4-HYDROXYCYCLOHEXYLCARBAMATE
TRANS-4-BOC-AMINO-1-CYCLOHEXANOL
TRANS-4-BOC-AMINOCYCLOHEXANOL
TRANS-(4-HYDROXY-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER
TRANS-4-N-BOC-AMINOCYCLOHEXANOL
TRANS-N-4-BOC-AMINOCYCLOHEXANOL
TRANS-N-BOC-4-AMINO-CYCLOHEXANOL
TRANS-T-BUTYL-4-HYDROXYCYCLOHEXYLCARBAMATE
trans-4-Aminocyclohexanol, N-BOC protected
trans-tert-Butyl-4-hydroxycyclohexylcarbamate
Boc-trans-4-aminocyclohexanol/CH63857
Boc-trans-4-aminocyclohexanol/CH85402
trans-4-Aminocyclohexanol, N-BOC protected 98% | [Molecular Formula]
C11H21NO3 | [MDL Number]
MFCD03844613 | [Molecular Weight]
215.29 | [MOL File]
111300-06-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
172-173°C | [Boiling point ]
337.7±31.0 °C(Predicted) | [density ]
1.06±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
Chloroform. Ethyl Acetate | [form ]
powder to crystal | [pka]
12.36±0.40(Predicted) | [color ]
White to Almost white | [InChIKey]
DQARDWKWPIRJEH-KYZUINATSA-N | [CAS DataBase Reference]
111300-06-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [Hazard Note ]
Irritant | [HS Code ]
2906190090 |
| Hazard Information | Back Directory | [Uses]
trans-4-(Boc-amino)cyclohexanol is an intermediate in the synthesis of potent activators of Heme-regulated inhibitor kinase. | [Synthesis]
Step 1: trans-4-Aminocyclohexanol hydrochloride (5.0 g, 33 mmol) was dissolved in 1,4-dioxane (100 mL) and the resulting solution was cooled to 0 °C. Aqueous sodium hydroxide solution (40 mL, 1 N) was slowly added and the reaction mixture was stirred for 15 minutes. Subsequently, di-tert-butyl dicarbonate (7.9 g, 36 mmol) pre-dissolved in 1,4-dioxane (65 mL) was added. The reaction mixture was stirred at room temperature for 14 hours. Upon completion of the reaction, the reaction mixture was neutralized with 1 N hydrochloric acid and extracted with ethyl acetate. The organic phase was washed sequentially with 1 N hydrochloric acid, water and saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated in vacuum to give the white solid product trans-4-BOC-aminocyclohexanol (7.0 g, 100% yield). Mass spectrometry analysis showed (M + H)+ = 216.15. | [References]
[1] Patent: US2005/54626, 2005, A1. Location in patent: Page/Page column 47
[2] Heterocycles, 2002, vol. 58, p. 471 - 504
[3] Patent: WO2007/67629, 2007, A1. Location in patent: Page/Page column 63 |
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