Triamcinolone acetonide synthesis
- Product Name:Triamcinolone acetonide
- CAS Number:76-25-5
- Molecular formula:C24H31FO6
- Molecular Weight:434.5
124-94-7
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$22.00/50mg
67-64-1
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76-25-5
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$25.00/100mg
Yield:76-25-5 93%
Reaction Conditions:
with boron trifluoride diethyl etherate at -10 - 0;
Steps:
2 Preparation of triamcinolone acetonide
Triamcinolone (II-2)(Purchased from Sinopharm Group Chemical Reagent Co., Ltd.) (8g, 20mmol)With acetone(III-2) (400 ml)Keep the temperature from -10 ° C to 0 ° CBetween slowly adding46.5% boron trifluoride etherSolution(2 ml),25 ° C overnight, stirring with saturated sodium bicarbonate solution (10ml),The reaction solution was concentrated to about 50 ml, and the solid precipitated by filtration, washed with water and dried to obtain 8.2 g of triamcinolone acetonide,Yield: 93%,
References:
Shanghai Specialization Pharmaceutical Technology Co., Ltd.;Shandong Tefaman Pharmaceutical Co., Ltd.;Wu Mingjun;Chen Weiming;Zhu Fuqiang CN103421075, 2017, B Location in patent:Paragraph 0034-0036
3870-07-3
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76-25-5
584 suppliers
$25.00/100mg
1524-86-3
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$265.00/250mg
76-25-5
584 suppliers
$25.00/100mg
124-94-7
287 suppliers
$22.00/50mg
76-25-5
584 suppliers
$25.00/100mg
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160512-79-8
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76-25-5
584 suppliers
$25.00/100mg