tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate synthesis
- Product Name:tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate
- CAS Number:114772-40-6
- Molecular formula:C18H19BrO2
- Molecular Weight:347.25
114772-36-0
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$90.00/10mg
114772-40-6
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$7.00/1g
Yield:114772-40-6 85%
Reaction Conditions:
with azobisisobutyronitrile;sodium acetate in acetic acid methyl ester;water;isopropyl alcohol;acetone
Steps:
4 EXAMPLE 4
EXAMPLE 4 268.0 kg of tert-butyl 4-methylbiphenyl-2'-carboxylate, 157.3 kg of DDH, 1.6 kg of AIBN, and 572 liters of methyl acetate are placed in a 1200-liter enamel stirring apparatus and the mixture is heated to 60° C. to 65° C. As soon as the solution has become practically colorless, 458 liters of solvent are distilled off under normal pressure and then 530 liters of isopropanol, 148 liters of water, and 16.4 kg of sodium acetate (anhydrous) are added. The resulting mixture is cooled to 15° C. to 25° C. and stirred for a further 1 hour. The product precipitated is separated by centrifugation, washed with a mixture of 530 liters of acetone and 148 liters of water, and dried. Yield: 295 kg of tert-butyl 4-bromomethylbiphenyl-2'-carboxylate (85% of theory).
References:
Schneider, Heinrich;Schneider, Margarete US2002/95042, 2002, A1
55666-42-7
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114772-40-6
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$7.00/1g
7148-03-0
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$10.00/1g
114772-40-6
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$7.00/1g
88-65-3
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$5.00/5g
114772-40-6
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114772-35-9
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114772-40-6
201 suppliers
$7.00/1g