tert-Butyl 3-fluoropyridin-4-ylcarbamate synthesis
- Product Name:tert-Butyl 3-fluoropyridin-4-ylcarbamate
- CAS Number:1260683-20-2
- Molecular formula:C10H13FN2O2
- Molecular Weight:212.22
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Yield:1260683-20-2 75%
Reaction Conditions:
in Petroleum ether;
Steps:
1 Step 1:
Step 1:
tert-butyl (3-fluoropyridin-4-yl)carbamate (3B)
Di-tert-butyl dicarbonate (262.0 g, 1.2 mol) was added dropwise to a stirred solution of 3-fluoropyridin-4-amine (112.0 g, 1.0 mol) dissolved in THF (1.5 L).
The resulting solution was stirred at rt for 6 h.
The mixture solution was evaporated to dryness, residues was suspended in petroleum ether (500 mL), stirred for 2 h, filtered, then the title compound (159.0 g, 75%) was obtained as white solid, which was used in the next step without further purification. LC-MS (ESI): m/z=213.2 [M+H]+.
References:
US2019/367515,2019,A1