ChemicalBook CAS DataBase List (R)-(+)-Propylene carbonate

(R)-(+)-Propylene carbonate synthesis

7synthesis methods

Product Name:(R)-(+)-Propylene carbonate
CAS Number:16606-55-6
Molecular formula:C4H6O3
Molecular Weight:102.09

R-Propylene carbonate, colorless to pale yellow transparent liquid, is an intermediate of anti-AIDS API, mainly used in laboratory research and development process and pharmaceutical research and development process. The mixtrue of R-1,2-propanediol ,Diethyl carbonate and sodium ethoxide was heated for 8 hours, and the ring closure reaction occurs to synthesize (R)-(+)-Propylene carbonate.

4254-14-2
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$5.00/1g

105-58-8
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$14.00/25g

16606-55-6
345 suppliers
$6.00/5g

Yield:16606-55-6 90%

Reaction Conditions:

with sodium ethanolate at 105 - 110; for 8 h;Large scale;

Steps:

1 The present invention is carried out according to the following stepsPreparation of R-propylene carbonate
R - Preparation of propylene carbonate,R-1,2-propanediol was added to a glass-lined reactor(38.05 kg, 500Mol),Diethyl carbonate(70.88 kg, 600 mol) and (3.4 kg, 50 mol) of sodium ethoxide,Heated to 105-110 ° C,Reaction for 8 hours,The reaction is terminated,The unreacted diethyl carbonate was distilled off under reduced pressure,Cooled to room temperature,Filter insoluble matter,The filtrate was evaporated to remove the solvent of product R - propylene carbonate 34.24 kg,Purity ≥ 99%The yield was 90%.

References:

Jingmen ShuaiBang Chemical Technology co., LTD;LIAO, JIN SONG CN105859781, 2016, A Location in patent:Paragraph 0011-0012

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