天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Nitroxoline
4008-48-4

Nitroxoline synthesis

7synthesis methods
5-nitroso-8-hydroxyquinoline hydrochloride

63450-86-2

Nitroxoline

4008-48-4

8-Hydroxy-5-nitrosoquinoline (10) was oxidized to 8-hydroxy-5-nitroquinoline (11) according to the method of Petrow and Sturgeon. The procedure was as follows: finely ground 8-hydroxy-5-nitrosoquinoline hydrochloride (10) (15.0 g, 0.7 mmol) was slowly added to a 500 mL beaker containing concentrated nitric acid (45 mL) and water (30 mL) under ice bath conditions. The reaction mixture was kept continuously stirred at 17 °C for 85 min. Upon completion of the reaction, an equal volume of cold water was added and the mixture was cooled to 0°C. Subsequently, the pH was adjusted to 13.0 with cold concentrated potassium hydroxide solution to prepare the basic. The red potassium salt formed decomposed after neutralization with acetic acid and the precipitate was collected by diafiltration and washed with cold water. Finally, the residue was recrystallized from ethanol to give yellow crystals of 8-hydroxy-5-nitroquinoline. The yield was 14.10 g (90.1% yield) and the melting point was 179 °C (literature value: 179.5-181.5 °C).

-

Yield:4008-48-4 90.1%

Reaction Conditions:

with nitric acid in water at 17; for 1.41667 h;Inert atmosphere;Cooling with ice;

Steps:

Synthesis of 8-hydroxy-5-nitroquinoline (11)
The oxidation of 8-hydroxy-5-nitrosoquinoline (10) to 8-hydroxy-5-nitroquinoline(11 ) was carried out according to the procedure ofPetrow and Sturgeon20. Finely grounded 8-hydroxy-5-nitrosoquinoline hydrochloride (10) (15.0 g, 0.7mmol) was added into a 500 mL beaker containingconcentrated nitric acid (45 mL) and water (30 mL)in an ice bath. The mixture was stirred for 85 min at17 °C. Equal volume of cold water was added andthe mixture cooled to 0 °C and alkaline was madewith cold concentrated potassium hydroxidesolution pH 13.0. The red potassium salt wasdecomposed on neutralization with acetic acid,filtered by suction and washed with water. Theresidue was recrystallized from ethanol to afford abright yellow crystal of 8-hydroxy-5-nitroquinoline.Yield 14.10 g (90.1%), mp 179 °C (lit 179.5-181.5°C)20.

References:

Oni, Timothy Toba;Okoro, Uchechukwu Chris;Ugwu, David Izuchukwu [Oriental Journal of Chemistry,2015,vol. 31,# 1,p. 371 - 378]

FullText

Nitroxoline Related Search: