天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List N,N-DIMETHYL-2-CHLOROACETOACETAMIDE
5810-11-7

N,N-DIMETHYL-2-CHLOROACETOACETAMIDE synthesis

3synthesis methods
-

Yield:-

Reaction Conditions:

Stage #1:N,N-Dimethylacetoacetamid with n-butyllithium;diisopropylamine in tetrahydrofuran;hexane at -78; for 0.5 h;Inert atmosphere;
Stage #2: with methyl chlorosulfate in tetrahydrofuran;hexane at -78; for 0.5 h;Inert atmosphere;

Steps:

α-chlorination of ketones
General procedure: To a solution of diisopropylamine (170 μL, 1.2 eq.) in dry THF (2 mL) in a flame dried round bottom flask under argon at 0 °C was added n-butyllithium (690 μL, 1.6 M in hexanes, 1.1 eq.), and the reaction mixture was stirred at this temperature for 15 minutes. It was then cooled to -78 °C and a solution of ketone (1) (1 mmol) in THF (2 mL) slowly added. Stirring at -78 °C was continued for a further 30 minutes and methyl chlorosulfate (100 μL, 1.1 eq.) was then added. After stirring at -78 °C for 30 minutes, the reaction was quenched with an aqueous saturated ammonium chloride solution (5 mL). The mixture was then extracted with dichloromethane (3 x 5 mL), the combined organic phases were dried with anhydrous magnesium sulfate and the solvent evaporated under vacuum affording the desired α-chloroketone 2.

References:

Silva, Saúl;Maycock, Christopher D. [Tetrahedron Letters,2018,vol. 59,# 13,p. 1233 - 1238] Location in patent:supporting information

N,N-DIMETHYL-2-CHLOROACETOACETAMIDE Related Search: