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ChemicalBook CAS DataBase List N-Acetylcysteine amide
38520-57-9

N-Acetylcysteine amide synthesis

6synthesis methods
N-Acetyl-L-cysteine methyl ester (10 g) under a flush of nitrogen was treated with ammonium hydroxide (28% aqueous, 66 mL) over 10 minutes at room temperature and stirred for 6 hours. The resulting solution was concentrated in vacuo and ethanol (100 mL) was added. Then the solution was concentrated again under reduced pressure at 48 00 then subjected to high vacuum overnight to afford N-acetylcysteine amide as a white crystalline solid.
N-Acetyl-L-cysteinamide
-

Yield:38520-57-9 93%

Reaction Conditions:

with ammonium hydroxide in water at 20; for 168 h;

Steps:

(R)-2-Acetylamino-3-merca to-propionamide (\2) (used during synthesis of 4)

(R)-2-Acetylamino-3-merca to-propionamide (2) (used during synthesis of 4) (R)-2-Acetylamino-3-mercapto-propionic acid methyl ester (177 mg, 1.0 mmol) was dissolved in NH4OH (28% aq., 5ml_) and the reaction mixture stirred at rt for 7 days. The solvent was evaporated in vacuo to give a white solid (150mg, 0.93 mmol, 93%).

References:

WO2015/181551,2015,A1 Location in patent:Page/Page column 35

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