N-(2-Hydroxyethyl)pyrrolidine synthesis
- Product Name:N-(2-Hydroxyethyl)pyrrolidine
- CAS Number:2955-88-6
- Molecular formula:C6H13NO
- Molecular Weight:115.17
Yield:2955-88-6 83%
Reaction Conditions:
in tetrahydrofuran; for 36 h;Heating / reflux;
Steps:
58
Intermediate (58) : Preparation of 2-(methyl-propyl-amino)-ethanol; Pyrrolidine (0.835ml, lOmmol) and 2-bromoethanol (0.28ml, 4.0mmol) were dissolved in THF (10ml). The reaction mixture was refluxed for 36 hours. The solvent was removed under reduced pressure. The residue was purified by column chromatography (dichlorome thane: methanol = 10:1) to give 380mg (yield: 83%, brown oil) of the target compound.[1141] 1U NMR(400D, CDCI): δ 3.64(t, J=5.6Hz, 2H), 2.65(t, J=5.6Hz, 2H), 2.56(m, 4H),1.78(m, 4H)
References:
WO2007/102679,2007,A1 Location in patent:Page/Page column 106
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