METHYL CHLORODIFLUOROACETATE synthesis
- Product Name:METHYL CHLORODIFLUOROACETATE
- CAS Number:1514-87-0
- Molecular formula:C3H3ClF2O2
- Molecular Weight:144.5
354-24-5
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$75.00/5 g
1514-87-0
262 suppliers
$9.00/1g
Yield:-
Reaction Conditions:
in methanol
Steps:
9 Preparation of the ester:
Preparation of the ester: The resulting pyridinium salt was taken up in 32.0 g (1.0 mole) of methanol (the salt dissolved immediately). After heating in an oil bath to 50° C., 148.9 g (1.0 mole) chlorodifluoroacetyl chloride were added dropwise with vigorous development of HCl. A gas chromatographic (GC) analysis of the reaction mixture after completion of the dropwise addition indicated that the acid chloride had been quantitatively converted to the ester. The resulting clear yellow solution was subsequently subjected to fine distillation over the 40 cm packed column. At a bottoms temperature of 80°-85° C. and a head temperature of 78°-79° C., methyl chlorodifluoroacetate was obtained in 99% purity.
References:
Feist;Heinz-Rudi;Pohlmeyer;Wilhelm;Frehse;Joachim;Rudolph;Werner;Braun;Max;Eichholz;Kerstin US5405991, 1995, A
598-99-2
166 suppliers
$21.21/10gm:
1514-87-0
262 suppliers
$9.00/1g