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ChemicalBook CAS DataBase List METHYL 4-AMINO-3-CHLORO-5-METHYLBENZOATE
202146-16-5

METHYL 4-AMINO-3-CHLORO-5-METHYLBENZOATE synthesis

2synthesis methods
18595-14-7 Synthesis
Methyl 4-amino-3-methylbenzoate

18595-14-7
301 suppliers
$8.00/5g

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Yield:202146-16-5 82%

Reaction Conditions:

with N-chloro-succinimide in dichloromethane at 20;

Steps:

3 Methyl 4-amino-3-chloro-5-methylbenzoate

Methyl 4-amino-3-methyl benzoate (5.0 g, 30.3 mmol) and dry dichloromethane (50 mL) were added in a threeneckedflask and stirred. N-chlorosuccinimide (4.85 g, 36.3 mmol) was added and the mixture was allowed to reactovernight at room temperature. The reaction mixture was poured into water (100 mL), extracted three times with dichloromethane.The organic phase was combined, dried with anhydrous sodium sulfate, filtered, concentrated to dry, andpurified by column to obtain the target compound (5.1 g, 82%) as a white solid.1H NMR (400 MHz, CDCl3): δ 7.85 (s, 1H), 7.67 (s, 1H), 4.33 (brs, 2H), 3.86 (s, 3H), 2.22 (s, 3H).

References:

EP3831824,2021,A1 Location in patent:Paragraph 0093-0095

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