METHYL 2-BROMO-3-NITROBENZOATE synthesis
- Product Name:METHYL 2-BROMO-3-NITROBENZOATE
- CAS Number:5337-09-7
- Molecular formula:C8H6BrNO4
- Molecular Weight:260.04
573-54-6
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74-88-4
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$15.00/10g
5337-09-7
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$20.00/250mg
Yield:5337-09-7 100%
Reaction Conditions:
with sodium carbonate in N,N-dimethyl-formamide at 60; for 4 h;
Steps:
36.a (a) methyl 2-bromo-3-nitrobenzoate
(a) methyl 2-bromo-3-nitrobenzoate To a solution of 2-bromo-3-nitrobenzoic acid (33.9 g, 138 mmol) in DMF (240 mL) were added Na2C03 (58.5 g, 552 mmol) and iodomethane (34 mL, 544 mmol). The reaction mixture was heated at 60 °C for 4 h. The reaction mixture was diluted with water (1.5 L) and extracted with Et20 (2 x 750 mL). The combined organic layers were washed with brine (500 mL) and concentrated to afford methyl 2-bromo-3-nitrobenzoate (36.78 g, 137 mmol, 100% yield) as a yellow solid. LC-MS (ES) m/z = 259.9, 261.9 [M+H]+.
References:
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED;KNIGHT, Steven David;LAFRANCE, Louis Vincent III;MCNULTY, Kenneth C.;ROMERIL, Stuart Paul;SEEFELD, Mark Andrew WO2014/195919, 2014, A1 Location in patent:Page/Page column 157
67-56-1
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573-54-6
246 suppliers
$8.00/1g
5337-09-7
101 suppliers
$20.00/250mg
573-54-6
246 suppliers
$8.00/1g
5337-09-7
101 suppliers
$20.00/250mg
57113-91-4
251 suppliers
$15.00/1g
5337-09-7
101 suppliers
$20.00/250mg
41085-43-2
198 suppliers
$6.00/1g
5337-09-7
101 suppliers
$20.00/250mg