天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Indol-1-yl-acetic acid
24297-59-4

Indol-1-yl-acetic acid synthesis

12synthesis methods
Ethyl 1-indoleacetate, 97%

61155-69-9

Indol-1-yl-acetic acid

24297-59-4

Step 2: Preparation of 2-(1H-indol-1-yl)acetic acid Ethyl 2-(1H-indol-1-yl)acetate (2.03 g, 10 mmol) was dissolved in ethanol (40 mL), aqueous sodium hydroxide solution (1 N, 50 mL) was added, and the reaction was stirred at room temperature for 1.5 hours. Upon completion of the reaction, the reaction solution was adjusted to slightly acidic with dilute hydrochloric acid and the mixture was subsequently concentrated under reduced pressure. The residue was extracted with ethyl acetate and the organic phase was washed with brine and the solvent was removed under reduced pressure to give pure 2-(1H-indol-1-yl)acetic acid (1.6 g, 87% yield), (LC/MS: m/z = 176.3 [M+H]+).

-

Yield: 92%

Reaction Conditions:

with sodium hydroxide;tetrabutylammomium bromide in water;benzene

Steps:

1 (1H-Indol-1-yl)acetic Acid
EXAMPLE 1 (1H-Indol-1-yl)acetic Acid To a solution of ethyl 2-bromoacetate (25 g, 0.15 mole) and indole (11.7 g, 0.1 mole) in 100 ml of benzene is added a solution of sodium hydroxide (25 g, 0.626 mole) in 50 ml of water. To the obtained mixture is added tetra-n-butylammonium bromide (1.6 g, 0.5 mmole). The mixture is stirred at 25° C. for 16 hours. The aqueous phase is acidified to pH 3. The organic phase is separated, dried and evaporated to give the title compound in 92% yield. NMR (DMSO-D6) ppm (δ) 5.05 (s,2); 6.50 (d, 1), 6.9- 7.8 (m, 5).

References:

Yeda Research and Development Co. Ltd. US4139703, 1979, A

Indol-1-yl-acetic acid Related Search: