Hexyl isocyanate synthesis
- Product Name:Hexyl isocyanate
- CAS Number:2525-62-4
- Molecular formula:C7H13NO
- Molecular Weight:127.18
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Yield:-
Reaction Conditions:
in tolueneReflux;
Steps:
4.2.2 General procedure for the preparation of α-amino acid ureas (3a-3l)
General procedure: A solution of triphosgene (0.15 g, 0.5 mmol) in toluene was dropwise added the amine (1 mmol) at room temperature. After the addition was completed, the reaction suspension was refluxed for 6 h, then toluene was evaporated, and the residue was taken up by CH2Cl2, then added to a solution of the α-amino acid methyl ester hydrochlorides (1.2mmol) with triethylamine (0.17 ml, 1.2 mmol) in CH2Cl2 dropwise at 0 °C. After the addition was completed, the reaction solution was stirred at room temperature for hours. Then CH2Cl2 evaporated, the residue was taken up with ethyl acetate and washed with brine. After being dried with MgSO4 and condensed, α-amino acid ureas (3a-3l) were obtained without further purification.
References:
Chen, Yu;Su, Li;Yang, Xinying;Pan, Wenyan;Fang, Hao [Tetrahedron,2015,vol. 71,# 49,p. 9234 - 9239]
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