天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List ethyl 1-acetyl-4-oxocyclohexane-1-carboxylate
72653-21-5

ethyl 1-acetyl-4-oxocyclohexane-1-carboxylate synthesis

7synthesis methods
-

Yield:72653-21-5 17%

Reaction Conditions:

with pyridine;acetic anhydride at 145; for 2 h;

Steps:

D28.3 Step 3: ethyl- l-acetyl-4-oxocyclohexanecarboxylate (D28-3)

To a stirred suspension of compound D28-2 (85 g, 310 mmol) in acetic anhydride (255 mL) was added pyridine (27 mL) and the mixture was stirred at 145 °C for 2 h. The solvent was removed under reduced pressure, the residue was suspended in water (200 mL) and extracted with EtOAc (3 x 100 mL). The combined organic layers were washed with water (100 mL), brine (100 mL), dried over Na2S04 and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (14% EtOAc/hexane as eluent) to provide compound D28-3 (11 g, 17%) as brown gum. FontWeight="Bold" FontSize="10" H NMR (CDCI3, 400 MHz): δ 4.28 (q, J = 7.2 Hz, 2H), 2.44-2.42 (m, 6H), 2.23-2.20 (m, 5H), 1.31 (t, J = 7.2 Hz, 3H).

References:

WO2015/129926,2015,A1 Location in patent:Page/Page column 199