DIMETHYL PIMELATE synthesis
- Product Name:DIMETHYL PIMELATE
- CAS Number:1732-08-7
- Molecular formula:C9H16O4
- Molecular Weight:188.22
Yield:1732-08-7 98.08%
Reaction Conditions:
with toluene-4-sulfonic acid for 7 h;Reflux;Large scale;
Steps:
3.1 Example 3
(1) Synthesis of dimethyl pimelate
In a 50-liter glass reactor with stirring and a thermometer, 5000 g of pimelic acid,25000ml of methanol, 200g of p-toluenesulfonic acid, start stirring, warming reflux 7h,Sampling raw material reaction is less than 0.5% is terminated;Then, the temperature was lowered to room temperature, and 300 g of sodium carbonate was added to neutralize p-toluenesulfonic acid. After filtration, methanol was removed from the filtrate to obtain 5911 g of crude dimethyl pimelate.The crude dimethyl pimelate was transferred to a 5000-ml single-mouth bottle for high-vacuum distillation. The oil bath temperature was 110°C.The degree of vacuum is 42 Pa, and the gas-phase collection temperature is 74° C., 5730 g of dimethyl pimelate can be obtained, with a content of 99.8% and a yield of 98.08%.
References:
Haimen Huaxiang Pharmaceutical Technology Co., Ltd.;Wu Tiansheng;Zhou Guang;Xu Benquan CN107417496, 2017, A Location in patent:Paragraph 0012; 0013; 0014
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