Dimethyl Glutarate synthesis
- Product Name:Dimethyl Glutarate
- CAS Number:1119-40-0
- Molecular formula:C7H12O4
- Molecular Weight:160.17
67-56-1
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1119-40-0
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Yield:1119-40-0 96%
Reaction Conditions:
with sulfuric acid at 20; for 18 h;
Steps:
Dimethyl glutarate (1l)7
Glutaric anhydride (29.4 mmol, 3.35 g) was dissolved in anhydrous MeOH (100 mL) and conc. H2SO4 (5.9 mmol, 0.31 mL) was added. After being stirred at room temperature for 18 h, the mixture was concentrated to a half volume and quenched with water (40 mL) afterwards. The aqueous phase was extracted with CH2Cl2 (3 x 50 mL), the combined organic phases were washed with brine (30 mL), dried over Na2SO4 and concentrated to give dimethyl glutarate 1l (4.53 g, 96%) as a colourless clear oil; 1H NMR (CDCl3): δ =1.96 (quint, J = 7.2 Hz, 2H), 2.39 (t, J = 7.2 Hz, 4H).
References:
Sivák, Ivan;Václav, Jakub;Berke?, Du?an;Kolarovi?, Andrej [Tetrahedron,2015,vol. 71,# 47,p. 8871 - 8875] Location in patent:supporting information
67-56-1
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1119-40-0
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1119-40-0
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1119-40-0
355 suppliers
$5.00/10g