Dimethyl 5-nitroisophthalate synthesis
- Product Name:Dimethyl 5-nitroisophthalate
- CAS Number:13290-96-5
- Molecular formula:C10H9NO6
- Molecular Weight:239.18
67-56-1
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13290-96-5
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Yield:13290-96-5 98%
Reaction Conditions:
with sulfuric acid for 3 h;Inert atmosphere;Reflux;
Steps:
1 Example 1. Synthesis of 5 - Nitroisophthalic Acid Dimethyl Ester
In a 100 mL round bottom flask equipped with a condenser, an electric stirrer and a thermometer5.0 g of 5-nitroisophthalic acid,Add 33.3ml of methanol, in the case of N2, stirring at room temperature, 3min or so, the solid completely dissolved, the solution colorless and clear and transparent, and then slowly add 1.0ml concentrated sulfuric acid, heating reflux, about 3h white solid precipitation, TLC (CH2Cl2: CH3OH = 10: 1), cooled, crystallized, filtered, washed with a small amount of water and the filter cake was dried to give dimethyl 5-nitroisophthalate. The yield was 98%.
References:
CN105254521,2016,A Location in patent:Paragraph 0025
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13290-96-5
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