ChemicalBook CAS DataBase List Octanohydroxamic Acid

Octanohydroxamic Acid synthesis

9synthesis methods

Product Name:Octanohydroxamic Acid
CAS Number:7377-03-9
Molecular formula:C8H17NO2
Molecular Weight:159.23

106-32-1

7377-03-9

To a 1000 mL four-necked flask was added hydroxylamine hydrochloride (48.7 g, 0.70 mol, 1.4 eq.), water (50 g), and ethanol (200 g, 2.3 times the volume), and stirred at room temperature until hydroxylamine hydrochloride was completely dissolved. Ethyl octanoate (86.7 g, 0.5 mol, 1.0 eq.) was then added and stirred at room temperature to form a two-phase system. The reaction mixture was cooled to 5-10°C and 40% KOH solution (168 g, 1.2 mol, 2.4 eq.) was added slowly and dropwise. After the dropwise addition, the reaction system was heated to 50~55°C and the reaction was held for 3 hours and monitored by gas chromatography (GC) until the ethyl octanoate material completely disappeared. After the reaction was completed, cooled to 5~10°C, slowly added concentrated hydrochloric acid (90 mL) to adjust the pH to 6.4~6.7, at which time a large amount of white solid precipitated. The solid was collected by filtration and dried at 50°C for 8 hours. The crude product was recrystallized with benzene to give 78.8 g of white flocculent solid in 91.1% yield.

124-07-2 Synthesis

124-07-2
744 suppliers
$6.00/25g

7377-03-9
335 suppliers
$5.00/5g

Yield:7377-03-9 95.81%

Reaction Conditions:

Stage #1: Octanoic acidwith acetic anhydride for 0.166667 h;
Stage #2: with hydroxylamine hydrochloride for 0.666667 h;

Steps:

5; 6 Example 5

29.13g n-octanoic acid (content 99%)And 21.05 g of acetic anhydride (content 97%) was added to the ball mill jar,Grinding for 10 min,Then add 14.11g hydroxylamine hydrochloride (content 98.5%),After continuing to grind for 40 minutes,Get a white solid product,It is the target collector product.After analysis and testing,The content of n-octyl hydroxydecanoic acid is 50.21%,Based on n-octanoic acidN-octyl hydroxamic acidThe yield was 95.81%.

References:

CN109761854,2019,A Location in patent:Paragraph 0076-0082

106-32-1 Synthesis

106-32-1
369 suppliers
$16.60/5g

7377-03-9
335 suppliers
$5.00/5g

References

111-11-5 Synthesis