BISPYRAZOLONE synthesis
- Product Name:BISPYRAZOLONE
- CAS Number:7477-67-0
- Molecular formula:C20H18N4O2
- Molecular Weight:346.38
Yield:7477-67-0 23% ，68195-63-1 35%
Reaction Conditions:
with caesium carbonate in ethanol at 100; for 0.416667 h;Microwave irradiation;Temperature;Solvent;Reagent/catalyst;
Steps:
1 Example 1 Preparation of edaravone-related substances
Then, 1.00 g of edaravone, 15 mL of ethanol, 0.20 g of cesium carbonate, a power of 50 W at a temperature of 100 ° C and a high-pressure microwave reaction for 25 min were added to the microwave reaction tube. The reaction was completed and the mixture was concentrated under reduced pressure to a solid mixture.The mobile phase consisted of ethyl acetate + n-hexane (ethyl acetate / n-hexane = 1/2) as the mobile phase with 200-300 mesh silica gel as the column, separated by elution and concentrated to dryness under reduced pressure. Dimer 0.23 g,Yield: 23%; trimer 0.35 g, yield 35%
References:
Anhui Tianyang Pharmaceutical Co., Ltd.;Pan Cunqing;Qi Chengliang;Zhang Shunlin;Zhang Li;Cao Yaoguo CN107098860, 2017, A Location in patent:Paragraph 0027-0028; 0029; 0030; 0031; 0032; 0033; 0034
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