BETA-(4-MORPHOLINO)PROPIOPHENONE HYDROCHLORIDE synthesis
- Product Name:BETA-(4-MORPHOLINO)PROPIOPHENONE HYDROCHLORIDE
- CAS Number:1020-16-2
- Molecular formula:C13H18ClNO2
- Molecular Weight:255.74
110-91-8
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50-00-0
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98-86-2
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1020-16-2
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Yield: 75%
Reaction Conditions:
with hydrogenchlorideReflux;Mannich Aminomethylation;
Steps:
3.1. General procedure for synthesis of Mannich bases
General procedure: Mannich bases were synthesized according to the given literature procedure. 23 A mixture of paraformaldehyde(1.80 g, 1.2 eq., 60.0 mmol), ketone (1.0 eq., 50.0 mmol), morpholine (4.35 g, 1.0 eq., 50.0 mmol), andhydrochloric acid (1.0 eq., 50.0 mmol) in ethanol was stirred at refl ux. The reaction was monitored by TLC.After the completion of the reaction, crude product was fi ltered and recrystallized in ethanol.3-Morpholino-1-phenylpropan-1-one hydrochloride (1a): White solid; mp 177-178 °C (lit. 175-178 °C); yield: 75%. 24
References:
Seyi?Tdanlio?lu, P?nar;Hanashalshahaby, Essam Hamied Ahmed;ünalero?lu, Canan [Turkish Journal of Chemistry,2018,vol. 42,# 6,p. 1598 - 1610]
50-00-0
892 suppliers
$10.00/25g
10024-89-2
131 suppliers
$5.00/5g
98-86-2
797 suppliers
$9.00/5g
1020-16-2
28 suppliers
$22.19/5g
108-86-1
525 suppliers
$10.00/5g
1020-16-2
28 suppliers
$22.19/5g
110-88-3
258 suppliers
$10.00/25g
10024-89-2
131 suppliers
$5.00/5g
98-86-2
797 suppliers
$9.00/5g
1020-16-2
28 suppliers
$22.19/5g