Berberine hydrochloride synthesis
- Product Name:Berberine hydrochloride
- CAS Number:633-65-8
- Molecular formula:C20H18NO4.Cl
- Molecular Weight:371.81
![Ethanone, 2-(5,8-dihydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizin-8-yl)-1-phenyl-](/CAS/20210305/GIF/51873-53-1.gif)
51873-53-1
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633-65-8
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Yield:633-65-8 68%
Reaction Conditions:
with hydrogenchloride in lithium hydroxide monohydrate at 20 - 80; for 10.5 h;
Steps:
11 Method 3. Reaction of Berberine Methyl Phenyl Ketone Adduct
46 mg of berberine methyl phenyl ketone adduct (0.10 mmol) was suspended in 1.1 ml of 0.10 N hydrochloric acid aqueous solution (0.11 mmol). The suspension was heated to about 80° C. and stirred for about 30 minutes, a clear yellow solution was obtained. A homogenous slurry was obtained after the suspension was cooled down to the room temperature and stirred for about 10 hours. The yellow solid was collected by filtration, washed with small amount of water, and then dried in the air. 30 mg of crystalline berberine chloride tetrahydrate was obtained. (68% yields).
References:
US11345697,2022,B1 Location in patent:Page/Page column 37
![2-Propanone, 1-(5,8-dihydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizin-8-yl)-](/CAS/20210305/GIF/39024-13-0.gif)
39024-13-0
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633-65-8
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549-21-3
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75-09-2
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549-21-3
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53811-50-0
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633-65-8
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