BENZENE ACETIC ACID, 4-[(2-CARBOXYPHENYL)METHOXY] synthesis
- Product Name:BENZENE ACETIC ACID, 4-[(2-CARBOXYPHENYL)METHOXY]
- CAS Number:55453-89-9
- Molecular formula:C16H14O5
- Molecular Weight:286.28
![Benzeneacetic acid, 4-[[2-(methoxycarbonyl)phenyl]methoxy]-, methyl ester](/CAS/20180808/GIF/1009378-92-0.gif)
1009378-92-0
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55453-89-9
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Yield:55453-89-9 83.1%
Reaction Conditions:
Stage #1: 4-(2-methoxycarbonylbenzyloxy)phenyl acetic acidwith N-benzyl-N,N,N-triethylammonium chloride;potassium hydroxide in ethanol; for 3 h;Reflux;Large scale;
Stage #2: with hydrogenchloride in water; pH=1 - 2;Large scale;
Steps:
2.2 Example 2 Step 2. Preparation of intermediate II
The intermediate I (3.2 kg, 10 . 2mol) and 34gTEBA into ethanol, stirring, by adding potassium hydroxide (1.2 kg, 21 . 4mol), heating reflow 3h, evaporate the ethanol, the residue for adding 20L water-soluble. Acidification with concentrated HCl to pH=1-2, generating a large amount of a buff solid, filtered, the filter cake is washed with water to neutral, buff solid obtained after drying 2.42 kg, II as intermediate, yield: 83.1%.
References:
CN104262318,2016,B Location in patent:Paragraph 0053; 0054
2417-73-4
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55453-89-9
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17138-28-2
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55453-89-9
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34040-62-5
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55453-89-9
137 suppliers
$20.00/1g