Bardoxolone synthesis
- Product Name:Bardoxolone
- CAS Number:890707-28-5
- Molecular formula:C9H11ClN2O
- Molecular Weight:198.65
870997-57-2
83 suppliers
$45.00/100mg
890707-28-5
175 suppliers
$5.00/100mg
Yield:890707-28-5 85%
Reaction Conditions:
with hydrogenchloride;dihydrogen peroxide;acetic acid at 5 - 20;
Steps:
Step-4 : 2-Amino-5-chloro-N,3-dimethylbenzamide
To a solution of 2-amino-N,3-dimethylbenzamide (4 g, 0.023) and hydrochloric acid (8 ml) in acetic acid (12 ml) was added hydrogen peroxide (30%, 0.032 mol) at 5-10°C. The reaction mixture was stirred for 5-6 h at room temperature. The progress of the reaction was monitored by HPLC. After completion of the reaction, water was added into the reaction mixture. The resultant solid product was isolated by filtration and washed with water. Yield: 85% and purity: 95%.
References:
EUROFINS ADVINUS LIMITED WO2021/33172, 2021, A1 Location in patent:Page/Page column 9; 16-17
20776-67-4
337 suppliers
$6.00/5g
74-89-5
0 suppliers
$13.44/25ML
890707-28-5
175 suppliers
$5.00/100mg
120374-68-7
9 suppliers
inquiry
593-51-1
558 suppliers
$21.00/100g
890707-28-5
175 suppliers
$5.00/100mg
201230-82-2
1 suppliers
inquiry
146948-68-7
74 suppliers
$67.00/10g
74-89-5
0 suppliers
$13.44/25ML
890707-28-5
175 suppliers
$5.00/100mg
120374-68-7
9 suppliers
inquiry
74-89-5
0 suppliers
$13.44/25ML
890707-28-5
175 suppliers
$5.00/100mg