2-ACETAMIDOPYRIDINE-5-BORONIC ACID PINACOL ESTER, 97% synthesis
- Product Name:2-ACETAMIDOPYRIDINE-5-BORONIC ACID PINACOL ESTER, 97%
- CAS Number:904326-87-0
- Molecular formula:C13H19BN2O3
- Molecular Weight:262.11
7169-97-3
166 suppliers
$9.00/1g
73183-34-3
586 suppliers
$6.00/5g
904326-87-0
84 suppliers
$55.00/250 mg
Yield: 89.1%
Reaction Conditions:
with (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;potassium acetate in 1,4-dioxane at 100;Inert atmosphere;Industrial scale;
Steps:
2.2 Step 2 Preparation of 2-acetylaminopyridine-5-boronic acid pinacol ester:
A 1 L four-necked flask equipped with a magnetic stirrer, a thermometer, a reflux condenser and a bubbler was charged56.41 g (0.264 mol) of 2-acetylamino-5-bromopyridine, 66.02 g (0.26 mol) of bis (pinacolato) diboron and 76.44 g450 mL of dioxane was added and stirred, 1.90 g (0.002589 mol) of ferrocenepalladium chloride was added under the protection of nitrogen, and the mixture was heated to 100 ° C. for 18 to 24 hours,TLC control to the end of the reaction, the temperature was precipitated solids, beating filtration, methanol was added 500mL dissolved, filtered and evaporated to dryness, plus heptane beating, to give the product 60.08g, yield 89.1%.
References:
Dalian Lianhua Chemical Co., Ltd.;Li Xin;Zheng Peng CN103601745, 2017, B Location in patent:Paragraph 0031; 0032
827614-64-2
196 suppliers
$14.00/250mg
108-24-7
0 suppliers
$14.00/250ML
904326-87-0
84 suppliers
$55.00/250 mg
142404-84-0
72 suppliers
$17.00/250mg
73183-34-3
586 suppliers
$6.00/5g
904326-87-0
84 suppliers
$55.00/250 mg
827614-64-2
196 suppliers
$14.00/250mg
904326-87-0
84 suppliers
$55.00/250 mg
7169-97-3
166 suppliers
$9.00/1g
25015-63-8
222 suppliers
$22.39/5G
904326-87-0
84 suppliers
$55.00/250 mg