天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 8-fluorooctanoic acid
353-25-3

8-fluorooctanoic acid synthesis

3synthesis methods
-

Yield:353-25-3 95%

Reaction Conditions:

with lithium hydroxide monohydrate in methanol;water;Inert atmosphere;

Steps:

8-Fluorooctanoic acid (9).

To a solution of 13 (360 mg, 2.05 mmol) stirring in 3:1 MeOH:H2O (12 mL) was added LiOH·H2O(430 mg, 6.15 mmol). The mixture was stirred overnight. Upon completion of the reaction, methanol was first removed under reduced pressure. The reaction mixture was diluted with ethyl acetate, then acidified with 1N HCl. The two layers were separated, and the aqueous layer was extracted with ethyl acetate.The combined organic layers were washed with brine, dried over MgSO4, and concentrated in vacuo to afford 9 as a colorless oil. Rf = 0.45 (3:1 hexanes/ethylacetate). 1H NMR (600 MHz, CDCl3) δ 4.38 - 4.49 (dt, J = 47.42, 6.13 Hz, 2H), 2.34 - 2.37 (t,J = 7.59 Hz, 2H), 1.62 - 1.74 (m,4H), 1.35 - 1.43 (m, 6H). 13C NMR (150 MHz, CDCl3) δ 179.0,84.9, 83.8, 34.0, 30.6, 30.5, 29.1, 25.2, 24.8. 19F NMR (565 MHz, CDCl3) δ -218.16.

References:

Kim, Eliana E.;Onyango, Evans O.;Fu, Liangfeng;Gribble, Gordon W. [Tetrahedron Letters,2015,vol. 56,# 48,p. 6707 - 6710] Location in patent:supporting information

8-fluorooctanoic acid Related Search: