7-TRIDECANONE synthesis
- Product Name:7-TRIDECANONE
- CAS Number:462-18-0
- Molecular formula:C13H26O
- Molecular Weight:198.34
3761-92-0
105 suppliers
$55.00/100ml
104863-66-3
21 suppliers
$95.00/500mg
462-18-0
84 suppliers
$55.00/1g
Yield:462-18-0 65%
Reaction Conditions:
in tetrahydrofuran at 0 - 20; for 4 h;Inert atmosphere;
Steps:
7.2 ATX-86: Step 2
To a solution of hexyl magnesium bromide (1.5 eq.) in THF (100 ml), taken in a 1 liter, two neck round bottom flask, stirred at 0° C. under nitrogen atmosphere, was added 38 g N-methoxy-N-methyloctanamide (1 eq.) solution (dissolved in 200 ml THF) and the resulting reaction mixture was stirred at room temperature for 4 hours. Progress of the reaction was monitored by TLC (10% EtOAc in hexane; Rf: 0.7). Reaction mass was quenched with saturated NH4Cl solution (250 ml) and then EtOAc (350 ml) was added. The organic layer was separated and the aqueous layer was washed with EtOAc (2×100 ml). Combined organic layers were concentrated under reduced pressure. Crude compound was subjected to column chromatography using (60-120 mesh silica gel; 2% EtOAc/hexane). Quantity produced, 44 g; yield, 65%; confirmed by Mass.
References:
Arcturus Therapeutics, Inc.;Payne, Joseph E.;Chivukula, Padmanabh;Karmali, Priya;Tanis, Steven P. US2018/169268, 2018, A1 Location in patent:Paragraph 0024; 0316-0318
111-14-8
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$14.00/25G
592-41-6
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$10.00/5g
111-71-7
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$13.50/100ML
462-18-0
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$55.00/1g
927-45-7
40 suppliers
$144.00/250mg
462-18-0
84 suppliers
$55.00/1g
111-71-7
232 suppliers
$13.50/100ML
462-18-0
84 suppliers
$55.00/1g